MRI ASSESSMENT OF THE BLOOD-BRAIN-BARRIER IN A HAMSTER MODEL OF SCRAPIE

被引：22

作者：

CHUNG, YL

WILLIAMS, A

BEECH, JS

WILLIAMS, SCR

BELL, JD

COX, IJ

HOPE, J

机构：

[1] INST ANIM HLTH,BBSRC & MRC NEUROPATHOGENESIS UNIT,EDINBURGH EH9 3JF,MIDLOTHIAN,SCOTLAND

[2] INST PSYCHIAT,DEPT NEUROL,LONDON SE5 8AF,ENGLAND

来源：

NEURODEGENERATION | 1995年 / 4卷 / 02期

基金：

英国医学研究理事会;

关键词：

BLOOD-BRAIN BARRIER; GD-DTPA; HAMSTER MODEL (263K); PROTON NUCLEAR MAGNETIC RESONANCE IMAGING; SCRAPIE;

D O I：

10.1006/neur.1995.0025

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Magnetic resonance (MR) imaging in combination with gadolinium-diethylenetriaminepenta-acetic acid (Gd-DTPA) enhancement was used to investigate the integrity of the blood-brain barrier in a hamster model of scrapie (263K) during the clinical phase of the disease. The post Gd-DPTA images of the infected hamster brain showed marked enhancement, which was not present in control animals. These results that blood-brain barrier function is disrupted in the clinically-affected animal.

引用

页码：203 / 207

页数：5

共 15 条

[1] THE LONGSTANDING MS LESION - A QUANTITATIVE MRI AND ELECTRON-MICROSCOPIC STUDY [J].