Conformational preference and diastereoselectivity of (S)-N-(alpha,beta-unsaturated carbonyl)-gamma-trityloxymethyl-gamma-butyrolactam

被引：16

作者：

Kanai, M

Muraoka, A

Tanaka, T

Sawada, M

Ikota, N

Tomioka, K

机构：

[1] OSAKA UNIV,INST SCI & IND RES,IBARAKI,OSAKA 567,JAPAN

[2] NATL INST RADIOL SCI,CHIBA 263,JAPAN

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 51期

关键词：

D O I：

10.1016/0040-4039(95)02025-K

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The conformational dependence of (S)-N-(alpha,beta-unsaturated carbonyl)-gamma-trityloxymethyl-gamma-butyrolactam 1 on metal salts was studied by means of theoretical calculations and NMR spectroscopy. The anti-conformation is dominant in the absence of metal salt, whereas the syn-form is predominant in the presence of magnesium perchlorate. Diastereofacial selection exhibited by 1 is reasonably correlated with its conformational dependency on metal salts.

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收藏

页码：9349 / 9352

页数：4

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