ANTINEURONAL ANTIBODIES IN PARANEOPLASTIC NEUROLOGICAL DISORDERS WITH SMALL-CELL LUNG-CARCINOMA

被引：4

作者：

MOLL, JWB ^{[1
]}

HENZENLOGMANS, SC ^{[1
]}

VECHT, CJ ^{[1
]}

机构：

[1] DR DANIEL DENHOED CANC CTR,DEPT NEUROL,POB 5201,3008 AE ROTTERDAM,NETHERLANDS

来源：

CLINICAL NEUROLOGY AND NEUROSURGERY | 1990年 / 92卷 / 03期

关键词：

antibodies; cancer; encephalitis; paraneoplastic;

D O I：

10.1016/0303-8467(90)90024-Y

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Auto-antibodies of the neuronal anti-nuclear antibody (anti-Hu) type were found in serum of three patients suspected of a paraneoplastic syndrome of the central nervous system. In all three a small cell carcinoma of the lung was detected. The sera showed bright staining of neuronal nuclei sparing the nucleolus. In two patients the antibody was of the IgG class (titers 1:1600 and 1:4000). In one patient only an IgM class antibody was present (titer 1:1000). The presence of the anti-Hu antibody strongly supports a diagnosis of a paraneoplastic neurological syndrome associated with small cell carcinoma of the lung. © 1990.

引用

页码：223 / 228

页数：6

共 17 条

[1]

Henson, Urich, Encephalomyelitis with carcinoma, Cancer and the nervous system, pp. 45-314, (1982)

[2]

Chad, Recht, Neurological paraneoplastic syndromes, Cancer Invest, 6, pp. 67-82, (1988)

[3]

Anderson, Rosenblum, Graus, Wiley, Posner, Autoantibodies in paraneoplastic syndromes with small-cell lung cancer, Neurology, 38, pp. 1391-1398, (1988)

[4]

Graus, Cordon-Cardo, Posner, Neuronal antinuclear antibody in sensory neuronopathy from lung cancer, Neurology, 35, pp. 43-538, (1985)

[5]

Greenlee, Brashear, Antibodies to cerebellar Purkinje cells in patients with paraneoplastic cerebellar degeneration and ovarian carcinoma, Annals of Neurology, 14, pp. 13-609, (1983)

[6]

Anderson, Rosenblum, Posner, Paraneoplastic cerebellar degeneration clinical-immunological correlations, Annals of Neurology, 24, pp. 67-559, (1988)

[7]

Smith, Finley, Lennon, Auto-antibodies in paraneoplastic cerebellar degeneration bind to cytoplasmic antigens of Purkinje cells in humans, rats and mice and are of multiple immunoglobulin classes, J Neuroimmunol, 18, pp. 37-48, (1988)

[8]

Corsellis, Goldberg, Norton, Limbic encephalitis and its association with carcinoma, Brain, 91, pp. 96-418, (1968)

[9]

Henson, Hoffman, Urich, Encephalomyelitis with carcinoma, Brain, 88, pp. 64-449, (1965)

[10]

Brain, Daniel, Greenfield, Subacute cortical cerebellar degeneration in relation to carcinoma, J Neurol Neurosurg Psychiatry, 14, pp. 59-75, (1951)

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