PROTEIN-TYROSINE PHOSPHORYLATION - AN ESSENTIAL COMPONENT OF FC-EPSILON-RI SIGNALING

被引:154
作者
BENHAMOU, M
SIRAGANIAN, RP
机构
[1] Marc Benhamou and Reuben P. Siraganian are, the Laboratory of Immunology, National Institute of Dental Research, Bethesda
来源
IMMUNOLOGY TODAY | 1992年 / 13卷 / 06期
关键词
D O I
10.1016/0167-5699(92)90152-W
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Mast cell and basophil activation can be achieved by antigen-mediated aggregation of cell surface Fc-epsilon-RI molecules. At least two signaling pathways are triggered by this activation. Both involve tyrosine phosphorylation. This aspect of Fc-epsilon-RI signaling is examined here in detail and its position in a complex network of post-binding events assessed.
引用
收藏
页码:195 / 197
页数:3
相关论文
共 15 条
[1]  
ALBER G, 1991, J BIOL CHEM, V266, P22613
[2]   SYNERGISTIC SIGNALS IN THE MECHANISM OF ANTIGEN-INDUCED EXOCYTOSIS IN 2H3 CELLS - EVIDENCE FOR AN UNIDENTIFIED SIGNAL REQUIRED FOR HISTAMINE-RELEASE [J].
BEAVEN, MA ;
GUTHRIE, DF ;
MOORE, JP ;
SMITH, GA ;
HESKETH, TR ;
METCALFE, JC .
JOURNAL OF CELL BIOLOGY, 1987, 105 (03) :1129-1136
[3]   TYROSINE PHOSPHORYLATION COUPLED TO IGE RECEPTOR-MEDIATED SIGNAL TRANSDUCTION AND HISTAMINE-RELEASE [J].
BENHAMOU, M ;
GUTKIND, JS ;
ROBBINS, KC ;
SIRAGANIAN, RP .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (14) :5327-5330
[4]  
BENHAMOU M, IN PRESS J BIOL CHEM
[5]   TYROSINE PHOSPHORYLATION IS AN EARLY SIGNALING EVENT COMMON TO FC RECEPTOR CROSS-LINKING IN HUMAN NEUTROPHILS AND RAT BASOPHILIC LEUKEMIA-CELLS (RBL-2H3) [J].
CONNELLY, PA ;
FARRELL, CA ;
MERENDA, JM ;
CONKLYN, MJ ;
SHOWELL, HJ .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1991, 177 (01) :192-201
[6]  
EISEMAN E, 1992, NATURE, V355, P78
[7]  
HOK WA, 1991, J IMMUNOL, V147, P2670
[8]   LIGAND STIMULATION OF TRANSFECTED AND ENDOGENOUS GROWTH-FACTOR RECEPTORS ENHANCES CYTOKINE PRODUCTION BY MAST-CELLS [J].
KEEGAN, AD ;
PIERCE, JH ;
ARTRIP, J ;
PLAUT, M ;
PAUL, WE .
EMBO JOURNAL, 1991, 10 (12) :3675-3682
[9]   A SPECIFIC COMBINATION OF SUBSTRATES IS INVOLVED IN SIGNAL TRANSDUCTION BY THE KIT-ENCODED RECEPTOR [J].
LEV, S ;
GIVOL, D ;
YARDEN, Y .
EMBO JOURNAL, 1991, 10 (03) :647-654
[10]   PHOSPHORYLATION AND DEPHOSPHORYLATION OF THE HIGH-AFFINITY RECEPTOR FOR IMMUNOGLOBULIN-E IMMEDIATELY AFTER RECEPTOR ENGAGEMENT AND DISENGAGEMENT [J].
PAOLINI, R ;
JOUVIN, MH ;
KINET, JP .
NATURE, 1991, 353 (6347) :855-858