DIASTEREOSELECTIVE ZIRCONOCENE-PROMOTED BICYCLIZATION-CARBONYLATION OF ALLYLICALLY METHYL-SUBSTITUTED ENYNES - SYNTHESIS OF (+)-IRIDOMYRMECIN

被引：61

作者：

AGNEL, G ^{[1
]}

OWCZARCZYK, Z ^{[1
]}

NEGISHI, E ^{[1
]}

机构：

[1] PURDUE UNIV,DEPT CHEM,W LAFAYETTE,IN 47907

来源：

TETRAHEDRON LETTERS | 1992年 / 33卷 / 12期

关键词：

D O I：

10.1016/S0040-4039(00)91669-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Allylically methyl-substituted 1,6-heptenynes, such as 3-methyl-1,6-octenyne, can be diastereoselectively converted to the corresponding bicyclic ketones, such as (5R,6S)-2,6-dimethylbicyclo[3.3.0]oct-1-en-3-one readily convertible to (+)-iridomyrmecin, the observed diastereomeric excesses of the bicyclization reaction being > 90%.

引用

页码：1543 / 1546

页数：4

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