BRAIN GLUCOSE-METABOLISM IN ALZHEIMERS-DISEASE

被引：41

作者：

SWERDLOW, R

MARCUS, DL

LANDMAN, J

KOOBY, D

FREY, W

FREEDMAN, ML

机构：

[1] NYU,MED CTR,DEPT MED,DIV GERIATR,NEW YORK,NY 10016

[2] ST PAUL RAMSEY MED CTR,ALZHEIMERS TREATMENT & RES CTR,ST PAUL,MN

来源：

AMERICAN JOURNAL OF THE MEDICAL SCIENCES | 1994年 / 308卷 / 03期

关键词：

ALZHEIMERS DISEASE; POSITRON EMISSION TOMOGRAPHY; TEMPORAL CORTEX; BRAIN GLUCOSE METABOLISM; DEMENTIA;

D O I：

10.1097/00000441-199409000-00003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In vitro determination of brain glucose metabolism in the temporal cortex from patients with Alzheimer's disease showed a marked decrease when compared with nondemented, age-matched control subjects. Additional determinations on normal human temporal cortex obtained at autopsy demonstrated an age-dependent decline in the rate of glucose use. These data provide an in vitro correlate for positron emission tomography studies that suggest decreased brain glucose use in Alzheimer's disease.

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收藏

页码：141 / 144

页数：4

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