GENERATION AND MIGRATION OF CELLS IN THE DEVELOPING STRIATUM

被引：160

作者：

HALLIDAY, AL ^{[1
]}

CEPKO, CL ^{[1
]}

机构：

[1] MASSACHUSETTS GEN HOSP,DEPT NEUROSCI,BOSTON,MA 02114

来源：

NEURON | 1992年 / 9卷 / 01期

关键词：

D O I：

10.1016/0896-6273(92)90216-Z

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The development of the rat striatum was investigated using a combination of two histochemically distinguishable retrovirus vectors. Using this method, it was possible to identify clonal boundaries within the embryonic striatum and thus determine patterns of proliferation, migration, and some lineal relationships. Several novel aspects of striatal histogenesis were discovered. Striatal progenitor cells do not exhibit a stem cell pattern of division between embryonic day 15 (E15) and E19; a progenitor-progeny relationship appears to exist for ventricular zone and subventricular zone (SVZ) cells; striatal progenitors produce a variety of clone types; some SVZ cells migrate radially, and some migrate tangentially within the SVZ; and radial glia and presumptive neurons can occur in the same clone.

引用

页码：15 / 26

页数：12

共 55 条

[1]

AUSTIN CP, 1990, DEVELOPMENT, V110, P713

[2] APPLICATION OF THE QUAIL-CHICK CHIMERA SYSTEM TO THE STUDY OF BRAIN-DEVELOPMENT AND BEHAVIOR [J].