MODULATION INVIVO OF BETA-ADRENERGIC-RECEPTOR SUBTYPES IN RAT BROWN ADIPOSE-TISSUE BY THE THERMOGENIC AGONIST RO-16-8714

被引：48

作者：

REVELLI, JP

MUZZIN, P

GIACOBINO, JP

机构：

[1] Departement de Biochimie medicale, Centre Medical Universitaire, 1211 Geneve 4

来源：

BIOCHEMICAL JOURNAL | 1992年 / 286卷

关键词：

D O I：

10.1042/bj2860743

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The number of beta-3-adrenergic receptors (AR) in plasma membranes from interscapular brown adipose tissue (IBAT) was decreased by 62% in lean Zucker rats treated with the thermogenic beta-adrenergic agonist Ro 16-8714 as compared with controls after 72 h of treatment. The loss of beta-3-AR number was preceded by a 93% decrease in the steady-state level of beta-3-AR mRNA at 30 h. Similar results were obtained in obese (fa/fa) Zucker rats. Ro 16-8714 had no effect on the number of beta-1- and beta-2-ARs in IBAT. This is the first report to demonstrate that the beta-3-AR in IBAT can be specifically down-regulated in vivo by exposure to a thermogenic agonist.

引用

页码：743 / 746

页数：4

共 23 条

[1] ATYPICAL BETA-ADRENOCEPTOR ON BROWN ADIPOCYTES AS TARGET FOR ANTI-OBESITY DRUGS
ARCH, JRS
AINSWORTH, AT
CAWTHORNE, MA
PIERCY, V
SENNITT, MV
THODY, VE
WILSON, C
WILSON, S
[J]. NATURE, 1984, 309 (5964) : 163 - 165
[2] PURIFICATION OF BIOLOGICALLY-ACTIVE GLOBIN MESSENGER-RNA BY CHROMATOGRAPHY ON OLIGOTHYMIDYLIC-ACID-CELLULOSE
AVIV, H
LEDER, P
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1972, 69 (06) : 1408 - &
[3] BLUMKAELIN D, 1991, ADV PHAR SC, P315
[4] BOUVIER M, 1989, J BIOL CHEM, V264, P16786
[5] STEREOSPECIFIC STIMULATION OF BROWN ADIPOCYTE RESPIRATION BY CATECHOLAMINES VIA BETA1-ADRENORECEPTORS
BUKOWIECKI, L
FOLLEA, N
PARADIS, A
COLLET, A
[J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1980, 238 (06): : E552 - E563
[6] CAMP STIMULATES TRANSCRIPTION OF THE BETA-2-ADRENERGIC RECEPTOR GENE IN RESPONSE TO SHORT-TERM AGONIST EXPOSURE
COLLINS, S
BOUVIER, M
BOLANOWSKI, MA
CARON, MG
LEFKOWITZ, RJ
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (13) : 4853 - 4857
[7] NONSHIVERING THERMOGENESIS IN RAT .2. MEASUREMENTS OF BLOOD-FLOW WITH MICROSPHERES POINT TO BROWN ADIPOSE-TISSUE AS DOMINANT SITE OF CALORIGENESIS INDUCED BY NORADRENALINE
FOSTER, DO
FRYDMAN, ML
[J]. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1978, 56 (01) : 110 - 122
[8] SUBCELLULAR FRACTIONATION OF BROWN ADIPOSE-TISSUE
GIACOBINO, JP
[J]. JOURNAL OF SUPRAMOLECULAR STRUCTURE, 1979, 11 (04): : 445 - 449
[9] PRIMARY STRUCTURE OF RAT CARDIAC BETA-ADRENERGIC AND MUSCARINIC CHOLINERGIC RECEPTORS OBTAINED BY AUTOMATED DNA-SEQUENCE ANALYSIS - FURTHER EVIDENCE FOR A MULTIGENE FAMILY
GOCAYNE, J
ROBINSON, DA
FITZGERALD, MG
CHUNG, FZ
KERLAVAGE, AR
LENTES, KU
LAI, J
WANG, CD
FRASER, CM
VENTER, JC
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1987, 84 (23) : 8296 - 8300
[10] DOWN-REGULATION OF BETA-ADRENERGIC RECEPTORS - AGONIST-INDUCED REDUCTION IN RECEPTOR MESSENGER-RNA LEVELS
HADCOCK, JR
MALBON, CC
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (14) : 5021 - 5025

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