GENOMIC IMPRINTING - DEFUSING THE OVARIAN TIME BOMB

被引：116

作者：

VARMUZA, S

MANN, M

机构：

[1] S. Varmuza and M. Mann are in the Department of Zoology, University of Toronto, Toronto

来源：

TRENDS IN GENETICS | 1994年 / 10卷 / 04期

关键词：

D O I：

10.1016/0168-9525(94)90212-7

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Why do mammals imprint their parental genomes? Imprinting is seen in many phyla, but that in mammals is by far the most dramatic. Is there something peculiar to mammals that calls for such a striking phenomenon? We propose that imprinting is a device that protects female mammals from the potential ravages of ovarian trophoblast disease. Without imprinting, the ovarian teratomas that frequently arise from parthenogenetically activated oocytes in situ might be capable of forming malignant trophoblast. An allele that favored imprinting would spread rapidly, because of the great increase in fitness associated with suppressing a lethal cancer of females.

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页码：118 / 123

页数：6

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