PHENYTOIN AND CARBAMAZEPINE - DIFFERENTIAL-EFFECTS ON COGNITIVE FUNCTION

被引：21

作者：

ALDENKAMP, AP ^{[1
]}

VERMEULEN, J ^{[1
]}

机构：

[1] MEER & BOSCH EPILEPSY CTR,DEPT NEUROPSYCHOL,2100 AA HEEMSTEDE,NETHERLANDS

来源：

SEIZURE | 1995年 / 4卷 / 02期

关键词：

COGNITIVE FUNCTION; EPILEPSY; COGNITIVE SIDE-EFFECTS OF AEDS; PHENYTOIN; CARBAMAZEPINE;

D O I：

10.1016/S1059-1311(95)80088-3

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This review summarizes the studies on the cognitive side-effects of two important antiepileptic drugs: phenytoin and carbamazepine. A large literature database was compiled through the DIMDI computer database and the inspection of recent reviews. Only scientific articles published in peer-reviewed journals during the last 25 years were selected. Of the 358 potentially relevant papers on cognitive effects of AEDs, a total of 16 studies have been found that have studied both carbamazepine and phenytoin. After excluding studies with designs that do not permit valid inferences regarding the cognitive effects of AEDs, only five studies remained. The evaluation of these studies reveal that our current knowledge allows us to draw conclusions about the cognitive side-effects of phenytoin and carbamazepine only with great caution. The claim in reviews that 'both drugs have an impact on cognitive function, PHT to a larger degree than CBZ' is simply not supported by valid 'high quality' data. The same is true for the overall conclusion in more recent reviews that 'drug-induced cognitive effects of these AEDs on cognitive function are probably mild or even negligible'. Apparently, the only information that we have is that the differential impact of PHT and CBZ on cognitive function is not extremely different. No conclusive and reconfirmed data are available on the absolute effects of CBZ and PHT (differences between the two drugs and a no-treatment condition). Our review summarizes some recommendations for future studies.

引用

页码：95 / 104

页数：10

共 40 条

[1]

Trimble, Anticonvulsant drugs and psychosocial development: phenobarbitone, sodium valproate, and benzodiazepines, Antiepileptic Drug Therapy in Pediatrics, pp. 201-217, (1983)

[2]

Trimble, Anticonvulsant drugs: mood and cognitive function, Epilepsy, Behaviour and Cognitive Function, pp. 135-145, (1987)

[3]

Trimble, Anticonvulsant drugs and cognitive function: a review of the literature, Epilepsia, 28, 3 S, pp. S37-S45, (1987)

[4]

Trimble, Thompson, Memory, anticonvulsant drugs and seizures, Acta Neurologica Scandinavica, 64, pp. 31-41, (1981)

[5]

Trimble, Thompson, Anticonvulsant drugs, cognitive function and behaviour, Epilepsia, 24, pp. S55-S63, (1983)

[6]

Trimble, Thompson, Sodium valproate and cognitive function, Epilepsia, 25, 1 S, pp. 60-64, (1984)

[7]

Trimble, Thompson, Anticonvulsant drugs, cognitive function and behaviour, Paediatric Perspectives on Epilepsy, pp. 141-148, (1985)

[8]

Trimble, Cull, Children of school age: the influence of antiepileptic drugs on behavior and intellect, Epilepsia, 29, pp. S15-S19, (1988)

[9]

Trimble, Thompson, Huppert, Anti-convulsant drugs and cognitive abilities, Advances in Epileptology, pp. 199-204, (1980)

[10]

Committee on Drugs, Behavioral and cognitive effects of anticonvulsant therapy, Pediatrics, 76, pp. 644-647, (1985)

← 1 2 3 4 →