MAJOR T-CELL RESPONSES IN MULTIPLE-SCLEROSIS

被引:48
作者
STEINMAN, L
WAISMAN, A
ALTMANN, D
机构
[1] WEIZMANN INST SCI,DEPT CELL BIOL,IL-76100 REHOVOT,ISRAEL
[2] HAMMERSMITH HOSP,CTR CLIN SCI,LONDON,ENGLAND
来源
MOLECULAR MEDICINE TODAY | 1995年 / 1卷 / 02期
基金
美国国家卫生研究院; 英国医学研究理事会;
关键词
D O I
10.1016/S1357-4310(95)92366-7
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Evidence is emerging that the major T- and B-cell response in multiple sclerosis (MS) is directed to a region of myelin basic protein (MBP) between residues 84 and 103. In rodent models of MS, immunization to this component of MBP evokes experimental autoimmune encephalomyelitis (EAE). T cells found in EAE lesions show similarities in the VJ and VDJ regions of their alpha and beta chains with T cells in MS lesions, and with T cells that are specific for MBPp84-103 isolated from patients with MS. If this region of MBP is critical in the pathogenesis of MS, then therapy aimed at controlling the immune response to this immunodominant region of MBP may be beneficial in treating MS.
引用
收藏
页码:79 / 83
页数:5
相关论文
共 30 条
[1]  
Valli, Et al., HLA class II molecules and their recognition by T cells from MS patients, J. Clin. Invest., 91, pp. 616-629, (1993)
[2]  
Ota, Et al., T cell recognition of an immunodominant MBP epitope in MS, Nature, 346, pp. 183-187, (1990)
[3]  
Martin, Et al., Fine specificity and HLA restriction of MBP-specific cytotoxic T cell lines from MS patients and healthy individuals, J. Immunol., 145, pp. 540-548, (1990)
[4]  
Pette, Et al., Myelin autoreactivity in MS: recognition of myelin basic protein in the context of HLA DR2 products by T lymphocytes of MS patients and healthy donors, Proc. Natl Acad. Sci. USA, 87, pp. 7968-7972, (1990)
[5]  
Zhang, Et al., Increased frequency of IL-2 responsive T cells specific for MBP and PLP in peripheral blood and CSF of patients with MS, J. Exp. Med., 179, pp. 973-984, (1994)
[6]  
Oksenberg, Et al., Selection for T cell receptor VDJβ-gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of MS, Nature, 362, pp. 68-70, (1993)
[7]  
Martin, Et al., Myelin basic protein-specific T cell responses in identical twins discordant or concordant for MS, Ann. Neurol., 34, pp. 524-535, (1993)
[8]  
Joshi, Usuku, Hauser, The T-cell response to myelin basic protein in familial MS: diversity of fine specificity, restricting elements, and TCR usage, Ann. Neurol., 34, pp. 385-393, (1993)
[9]  
Meinl, Et al., Myelin basic protein-specific T lymphocyte repertoire in MS, J. Clin. Invest., 92, pp. 2633-2643, (1993)
[10]  
Zhang, Et al., MHC-restricted depletion of human myelin basic protein-reactive T cells by T-cell vaccination, Science, 261, pp. 1451-1454, (1993)