OPTIMIZATION OF SPRAY-DRIED AND SPRAY-CONGEALED LIPID MICROPELLETS AND CHARACTERIZATION OF THEIR SURFACE-MORPHOLOGY BY SCANNING ELECTRON-MICROSCOPY

被引:123
作者
ELDEM, T [1 ]
SPEISER, P [1 ]
HINCAL, A [1 ]
机构
[1] SWISS FED INST TECHNOL,DEPT PHARM,CH-8092 ZURICH,SWITZERLAND
关键词
LIPID MICROPELLETS; SPRAY-DRYING; SPRAY-CONGEALING; STEROID CARRIERS; SCANNING ELECTRON MICROSCOPY; TRIGLYCERIDE;
D O I
10.1023/A:1015874121860
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Lipid micropellets prepared from glycerides and phospholipids may be a physiological drug carrier system for improving the intestinal absorption of lipophilic drugs. They can be prepared by spray-drying and spray-congealing processes. In this study, formulation and optimization parameters of spray-dried and -congealed lipid pellets in the micro- and nanometer size were investigated. The rapid evaporation of solvents from the droplets, which in turn causes a rapid solidification, influenced the crystalline structures of spray-dried glycerides. Moreover, solvents, the chain length, and the type of lipids and drugs used in the formulations of spray-dried micropellets affected the surface morphology of the micropellets. In contrast to the variations of the surface structure of spray-dried micropellets, formulated spray-congealed micropellets possessed smooth surface properties. The surface morphology and microstructure of both types of micropellets were characterized by SEM.
引用
收藏
页码:47 / 54
页数:8
相关论文
共 12 条
  • [1] AMELOT MP, 1986, ATOMIZATION SPRAY TE, V2, P299
  • [2] DEASY PB, 1984, MICROENCAPSULATION R
  • [3] DEMAN JM, 1985, FOOD MICROSTRUCT, V4, P233
  • [4] ELDEM T, 1989, PHARMAZIE, V44, P444
  • [5] ELDEM T, UNPUB
  • [6] Hagemann J. W., 1988, CRYSTALLIZATION POLY
  • [7] POLYMORPHISM OF INTERESTERIFIED TRIGLYCERIDES AND TRIGLYCERIDE MIXTURES
    HERNQVIST, L
    HERSLOF, B
    HERSLOF, M
    [J]. FETTE SEIFEN ANSTRICHMITTEL, 1984, 86 (10): : 393 - 397
  • [8] ON THE STRUCTURE OF TRIGLYCERIDES IN THE LIQUID-STATE AND FAT CRYSTALLIZATION
    HERNQVIST, L
    [J]. FETTE SEIFEN ANSTRICHMITTEL, 1984, 86 (08): : 297 - 300
  • [9] HERNQVIST L, 1984, THESIS U LUND LUND
  • [10] Masters K., 1985, SPRAY DRYING HDB