A PSEUDOGENE ON THE X-CHROMOSOME FOR THE HUMAN TRIFUNCTIONAL ENZYME MTHFD (METHYLENETETRAHYDROFOLATE DEHYDROGENASE METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE FORMYLTETRAHYDROFOLATE SYNTHETASE)

被引：9

作者：

ITALIANO, C

JOHN, SWM

HUM, DW

MACKENZIE, RE

ROZEN, R

机构：

[1] MCGILL UNIV,MONTREAL CHILDRENS HOSP,RES INST,DEPT PEDIAT,2300 TUPPER ST,MONTREAL H3H 1P3,QUEBEC,CANADA

[2] MCGILL UNIV,MONTREAL CHILDRENS HOSP,RES INST,DEPT BIOL,MONTREAL H3H 1P3,QUEBEC,CANADA

[3] MCGILL UNIV,MONTREAL CHILDRENS HOSP,RES INST,DEPT BIOCHEM,MONTREAL H3H 1P3,QUEBEC,CANADA

来源：

GENOMICS | 1991年 / 10卷 / 04期

关键词：

D O I：

10.1016/0888-7543(91)90201-O

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The human trifunctional folate-dependent protein MTHFD has been mapped to chromosome 14q24 and to the X chromosome at Xp11. The MTHFD sequence on the X chromosome was identifled by screening an X-chromosome-specific library. Amplification by the polymerase chain reaction (PCR) and sequencing of PCR products indicate that the sequence is an intronless pseudogene. © 1991.

引用

页码：1073 / 1074

页数：2

共 9 条

[1]

DORFMAN DM, 1989, BIOTECHNIQUES, V7, P569

[2]

HARDS RG, 1986, AM J HUM GENET, V39, P179

[3]

HUM DW, 1988, J BIOL CHEM, V263, P15946

[4]

JOHN SWM, 1989, AM J HUM GENET, V45, P905

[5]

MANIATIS T, 1982, MOL CLONING

[6] GENE DELETION AND RESTRICTION FRAGMENT LENGTH POLYMORPHISMS AT THE HUMAN ORNITHINE TRANSCARBAMYLASE LOCUS [J].

ROZEN, R ;

FOX, J ;

FENTON, WA ;

HORWICH, AL ;

ROSENBERG, LE .

NATURE, 1985, 313 (6005) :815-817

[7]

ROZEN R, 1989, AM J HUM GENET, V44, P781

[8]

SHANNON KW, 1986, J BIOL CHEM, V261, P2266

[9] ALLELE-SPECIFIC ENZYMATIC AMPLIFICATION OF BETA-GLOBIN GENOMIC DNA FOR DIAGNOSIS OF SICKLE-CELL ANEMIA [J].

WU, DY ;

UGOZZOLI, L ;

PAL, BK ;

WALLACE, RB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (08) :2757-2760

← 1 →