RSU-1069, A NITROIMIDAZOLE CONTAINING AN AZIRIDINE GROUP - BIOREDUCTION GREATLY INCREASES CYTOTOXICITY UNDER HYPOXIC CONDITIONS

被引:96
作者
STRATFORD, IJ
ONEILL, P
SHELDON, PW
SILVER, ARJ
WALLING, JM
ADAMS, GE
机构
基金
英国医学研究理事会;
关键词
D O I
10.1016/0006-2952(86)90566-6
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:105 / 109
页数:5
相关论文
共 29 条
[1]   STRUCTURE-ACTIVITY-RELATIONSHIPS IN THE DEVELOPMENT OF HYPOXIC CELL RADIOSENSITIZERS .1. SENSITIZATION EFFICIENCY [J].
ADAMS, GE ;
CLARKE, ED ;
FLOCKHART, IR ;
JACOBS, RS ;
SEHMI, DS ;
STRATFORD, IJ ;
WARDMAN, P ;
WATTS, ME ;
PARRICK, J ;
WALLACE, RG ;
SMITHEN, CE .
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 1979, 35 (02) :133-150
[2]   RSU-1069, A 2-NITROIMIDAZOLE CONTAINING AN ALKYLATING GROUP - HIGH-EFFICIENCY AS A RADIOSENSITIZER AND CHEMOSENSITIZER INVITRO AND INVIVO [J].
ADAMS, GE ;
AHMED, I ;
SHELDON, PW ;
STRATFORD, IJ .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1984, 10 (09) :1653-1656
[3]   RADIATION SENSITIZATION AND CHEMOPOTENTIATION - RSU-1069, A COMPOUND MORE EFFICIENT THAN MISONIDAZOLE INVITRO AND INVIVO [J].
ADAMS, GE ;
AHMED, I ;
SHELDON, PW ;
STRATFORD, IJ .
BRITISH JOURNAL OF CANCER, 1984, 49 (05) :571-577
[4]   HYPOXIA-MEDIATED NITRO-HETEROCYCLIC DRUGS IN THE RADIOTHERAPY AND CHEMOTHERAPY OF CANCER - AN OVERVIEW [J].
ADAMS, GE ;
STRATFORD, IJ .
BIOCHEMICAL PHARMACOLOGY, 1986, 35 (01) :71-76
[5]   ELECTRON-AFFINIC SENSITIZATION .7. CORRELATION BETWEEN STRUCTURES ONE-ELECTRON REDUCTION POTENTIALS, AND EFFICIENCIES OF NITROIMIDAZOLES AS HYPOXIC CELL RADIOSENSITIZERS [J].
ADAMS, GE ;
FLOCKHART, IR ;
SMITHEN, CE ;
STRATFORD, IJ ;
WARDMAN, P ;
WATTS, ME .
RADIATION RESEARCH, 1976, 67 (01) :9-20
[6]   NON-PROTEIN THIOLS AND CELLULAR-RESPONSE TO DRUGS AND RADIATION [J].
BIAGLOW, JE ;
VARNES, ME ;
ASTOR, M ;
HALL, EJ .
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1982, 8 (3-4) :719-723
[7]  
BROWN JM, 1981, INT J RADIAT ONCOL, V7, P695
[8]   REGULATION OF DNA-LIGASE ACTIVITY BY POLY(ADP-RIBOSE) [J].
CREISSEN, D ;
SHALL, S .
NATURE, 1982, 296 (5854) :271-272
[9]   CLINICAL TESTING OF RADIOSENSITIZER RO 07-0582 - EXPERIENCE WITH MULTIPLE DOSES [J].
DISCHE, S ;
SAUNDERS, MI ;
LEE, ME ;
ADAMS, GE ;
FLOCKHART, IR .
BRITISH JOURNAL OF CANCER, 1977, 35 (05) :567-579
[10]   GENETICS OF HUMAN CELL LINES .3. INCORPORATION OF 5-BROMODEOXYURIDINE AND 5-IODODEOXYURIDINE INTO THE DEOXYRIBONUCLEIC ACID OF HUMAN CELLS AND ITS EFFECT ON RADIATION SENSITIVITY [J].
DJORDJEVIC, B ;
SZYBALSKI, W .
JOURNAL OF EXPERIMENTAL MEDICINE, 1960, 112 (03) :509-531