A SHORT, CONVERGENT SYNTHESIS OF ARISTOLINDIQUINONE

被引：21

作者：

BOTHA, ME ^{[1
]}

GILES, RGF ^{[1
]}

YORKE, SC ^{[1
]}

机构：

[1] UNIV CAPE TOWN,DEPT CHEM,RONDEBOSCH 7700,SOUTH AFRICA

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1991年 / 01期

关键词：

D O I：

10.1039/p19910000085

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Aristolindiquinone, 2,5-dihydroxy-3,8-dimethyl-1,4-naphthoquinone 1, is synthesised by the regiochemical addition of 1-methoxy-1-trimethylsiloxypenta-1,3-diene 2 to 5-bromo-2-methoxy-3-methyl-1,4-benzoquinone 3. The regioisomer 2,8-dihydroxy-3,5-dimethyl-1,4-naphthoquinone 4 is prepared by reaction of the same diene 2 with 2-methoxy-3-methyl-1,4-benzoquinone 11. The former reaction readily provided sufficient quantities of aristolindiquinone 1 for biological evaluation for fertility regulation in rats, for which purpose it was found to be inactive.

引用

页码：85 / 88

页数：4

共 22 条

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