CLONING AND NUCLEOTIDE-SEQUENCE OF THE CHIMPANZEE C-MYC GENE

被引:10
作者
ARGAUT, C [1 ]
RIGOLET, M [1 ]
ELADARI, ME [1 ]
GALIBERT, F [1 ]
机构
[1] HOP ST LOUIS,CTR HAYEM,RECOMBINAISONS GENET LAB,CNRS,UPR 41,F-75475 PARIS 10,FRANCE
关键词
RECOMBINANT DNA; MOLECULAR EVOLUTION; PRIMATE; COMPARATIVE STUDY; ONCOGENE; TRANSITIONS; TRANSVERSIONS;
D O I
10.1016/0378-1119(91)90056-H
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
A DNA fragment covering the chimpanzee c-myc locus was cloned from the DNA of peripheral blood lymphocytes, sequenced, and compared to its human c-myc counterpart. The two nucleotide sequences were found to be highly homologous (99%). The divergence rate between the two species was 0.4% in exons and 1.7% in introns. The different TATA-boxes described in the human myc gene were also identified in the chimpanzee sequence and an open reading frame (ORF) was observed which overlaps the chimpanzee c-myc first exon. This latter ORF contained three silent mutations with regard to the human region, whereas the chimpanzee Myc oncoprotein coded by exons 2 and 3 differed by two amino acids from the human one.
引用
收藏
页码:231 / 237
页数:7
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