GRAFTING OF LEG ULCERS WITH UNDIFFERENTIATED KERATINOCYTES

被引：15

作者：

BRYSK, MM

RAIMER, SS

PUPO, R

BELL, T

RAJARAMAN, S

机构：

[1] UNIV TEXAS,MED BRANCH,DEPT PSYCHOPHYSIOL,GALVESTON,TX 77550

[2] UNIV TEXAS,MED BRANCH,DEPT PATHOL,GALVESTON,TX 77550

[3] UNIV TEXAS,MED BRANCH,DEPT MICROBIOL,GALVESTON,TX 77550

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 1991年 / 25卷 / 02期

关键词：

D O I：

10.1016/0190-9622(91)70188-8

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

A procedure for transplanting cultured human keratinocytes has been developed and used successfully to treat patients with persistent leg ulcers. Shave excisions of donor skin of 1 cm2 or less were expanded in culture in 1 week to cover wounds as large as 90 cm2. The uniqueness of this system is the use of a biochemically modified surgical dressing that permits the transplantation of undifferentiated cells. Several hours after inoculation, trypsinized single cells become attached to the dressing and are ready for grafting. Seven of eight persistent stasis ulcers completely reepithelialized after application of the modified surgical dressing with undifferentiated keratinocytes.

引用

页码：238 / 244

页数：7

共 19 条

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