NEW APPROACHES TO THE TREATMENT OF AGE-RELATED BRAIN DISORDERS

被引：11

作者：

DAPRADA, M

机构：

[1] Pharma Research Department, F. Hoffmann-La Roche Ltd., Basel

来源：

CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES | 1991年 / 18卷 / 03期

关键词：

D O I：

10.1017/S0317167100032492

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Two novel reversible enzyme inhibitors involved in monoamine metabolism are described. The novel and reversible inhibitors are the catechol-O-methyl-transferase (COMT) inhibitor, Ro 40-7592 (3,4-dihydroxy-4'-methyl-5-nitrobenzophenone), and the monoamine oxidase type-B (MAO-B) inhibitor, Ro 19-6327 (N-(2-aminoethyl)-5-chloro-2-pyridine carboxamide HC1). These may be of special therapeutic benefit in Parkinson's and Alzheimer's diseases.

引用

页码：384 / 386

页数：3

共 21 条

[1] INCREASED LIFE EXPECTANCY RESULTING FROM ADDITION OF L-DEPRENYL TO MADOPAR TREATMENT IN PARKINSONS-DISEASE - A LONGTERM STUDY [J].