ENZYMATIC CONVERSION OF DEUTERATED ANALOGS OF DELTA-L-ALPHA-AMINOADIPOYL-L-CYSTEINYL-D-ALLYLGLYCINE, AN UNNATURAL SUBSTRATE FOR ISOPENICILLIN N SYNTHASE - A UNIFIED THEORY OF 2ND RING-CLOSURE

被引：7

作者：

BALDWIN, JE ^{[1
]}

BRADLEY, M ^{[1
]}

TURNER, NJ ^{[1
]}

ADLINGTON, RM ^{[1
]}

PITT, AR ^{[1
]}

DEROME, AE ^{[1
]}

机构：

[1] UNIV OXFORD,OXFORD CTR MOLEC SCI,OXFORD OX1 3QY,ENGLAND

来源：

TETRAHEDRON | 1991年 / 47卷 / 38期

关键词：

D O I：

10.1016/S0040-4020(01)91016-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The enzyme Isopenicillin N Synthase catalyses the conversion of the modified substrate delta-L-alpha-aminoadipoyl-L-cysteinyl-D-allylglycine to six beta-lactam containing metabolites. Eight tripeptides deuterated in the allylglycine moiety have been prepared and the stereochemical course of their cyclization to the beta-lactam containing metabolites has been investigated.

引用

页码：8223 / 8242

页数：20

共 23 条

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