AN ARTIFICIAL ALLOSTERIC SYSTEM - REGULATION OF A BIOMIMETIC REDUCTION (NADH MODEL) BY POTASSIUM-IONS

被引:16
作者
PIERRE, JL
GAGNAIRE, G
CHAUTEMPS, P
机构
[1] Laboratoire de Chimie Biomimétique, LEDSS, URA CNRS 332, 38041 Grenoble
关键词
NADH MODEL; ALLOSTERIC REGULATION; CHARGE TRANSFER INTERACTION AND TRANSITION STATE;
D O I
10.1016/0040-4039(92)88054-9
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
An acyclic glycol ether ligand with both a quinone and a dimethoxybenzene as terminal groups, reacts with the NADH model 1-propyl-1,4 dihydronicotinamide. The reduction of the quinone exhibits a 30 fold kinetic enhancement in the presence of potassium ions. An effective charge transfer interaction in the transition state of the reduction is probably responsable of this activation effect. The results are discussed in terms of a potassium induced conformational change that mimics allosteric effects.
引用
收藏
页码:217 / 220
页数:4
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