EVIDENCE FOR L-DOPA SYSTEMS RESPONSIBLE FOR CARDIOVASCULAR CONTROL IN THE NUCLEUS-TRACTUS-SOLITARII OF THE RAT

被引：62

作者：

KUBO, T ^{[1
]}

YUE, JL ^{[1
]}

GOSHIMA, Y ^{[1
]}

NAKAMURA, S ^{[1
]}

MISU, Y ^{[1
]}

机构：

[1] YOKOHAMA CITY UNIV, SCH MED, DEPT PHARMACOL, YOKOHAMA 236, JAPAN

来源：

NEUROSCIENCE LETTERS | 1992年 / 140卷 / 02期

关键词：

L-DOPA; D-DOPA; L-DOPA METHYL ESTER; COMPETITIVE L-DOPA ANTAGONIST; DOPAMINE; NORADRENALINE; NUCLEUS-TRACTUS-SOLITARII; BLOOD PRESSURE; RELEASE OF ENDOGENOUS DOPA; RAT;

D O I：

10.1016/0304-3940(92)90090-T

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Microinjections of L-DOPA (10-100 ng) into the medial area of the nucleus tractus solitarii (NTS) led to dose-dependent decreases in arterial blood pressure and heart rate in rats treated with i.p. 3-hydroxybenzylhydrazine, a central inhibitor of DOPA decarboxylase, or similarly with intraventricular 6-hydroxydopamine. D-DOPA, dopamine or noradrenaline (100 ng) produced no effect. L-DOPA methyl ester (1-mu-g), a competitive antagonist for L-DOPA, microinjected into NTS. blocked the depressor and bradycardic responses to L-DOPA. High K+ (40 mM) released endogenous DOPA in a Ca2+-dependent manner from slices of the rat dorsomedial medulla including NTS. These results support the hypothesis that there exist systems Of L-DOPA itself responsible for cardiovascular regulation in NTS of rats. This regulatory action Of L-DOPA seems to be postsynaptic in nature.

引用

页码：153 / 156

页数：4

共 17 条

[1] EFFECT OF VARIOUS DECARBOXYLASE INHIBITORS ON CEREBRAL METABOLISM OF DIHYDROXYPHENYLALANINE [J].

BARTHOLINI, G ;

PLETSCHER, A .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1969, 21 (05) :323-+

[2] L-DOPA ESTERS AS POTENTIAL PRODRUGS .3. BEHAVIORAL ACTIVITY IN EXPERIMENTAL-MODELS OF PARKINSONS-DISEASE [J].

COOPER, DR ;

MARREL, C ;

VANDEWATERBEEMD, H ;

TESTA, B ;

JENNER, P ;

MARSDEN, CD .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1987, 39 (08) :627-635

[3] DEGENERATION STUDIES OF PRIMARY AFFERENTS OF 9TH + XTH CRANIAL NERVES IN CAT [J].

COTTLE, MK .

JOURNAL OF COMPARATIVE NEUROLOGY, 1964, 122 (03) :329-&

[4]

GOSHIMA Y, 1991, J PHARMACOL EXP THER, V258, P466

[5] TRANSMITTER-LIKE RELEASE OF ENDOGENOUS 3,4-DIHYDROXYPHENYLALANINE FROM RAT STRIATAL SLICES [J].

GOSHIMA, Y ;

KUBO, T ;

MISU, Y .

JOURNAL OF NEUROCHEMISTRY, 1988, 50 (06) :1725-1730

[6] PICOMOLAR CONCENTRATIONS OF L-DOPA STEREOSELECTIVELY POTENTIATE ACTIVITIES OF PRESYNAPTIC BETA-ADRENOCEPTORS TO FACILITATE THE RELEASE OF ENDOGENOUS NORADRENALINE FROM RAT HYPOTHALAMIC SLICES [J].

GOSHIMA, Y ;

NAKAMURA, S ;

OHNO, K ;

MISU, Y .

NEUROSCIENCE LETTERS, 1991, 129 (02) :214-216

[7] BIPHASIC ACTIONS OF L-DOPA ON THE RELEASE OF ENDOGENOUS NORADRENALINE AND DOPAMINE FROM RAT HYPOTHALAMIC SLICES [J].

GOSHIMA, Y ;

KUBO, T ;

MISU, Y .

BRITISH JOURNAL OF PHARMACOLOGY, 1986, 89 (01) :229-234

[8] RELEASE BY ELECTRICAL-STIMULATION OF ENDOGENOUS GLUTAMATE, GAMMA-AMINOBUTYRIC ACID, AND OTHER AMINO-ACIDS FROM SLICES OF THE RAT MEDULLA-OBLONGATA [J].

KIHARA, M ;

MISU, Y ;

KUBO, T .

JOURNAL OF NEUROCHEMISTRY, 1989, 52 (01) :261-267

[9]

KUBO T, 1978, ARCH INT PHARMACOD T, V232, P166

[10] PHARMACOLOGICAL CHARACTERIZATION OF THE ALPHA-ADRENOCEPTORS RESPONSIBLE FOR A DECREASE OF BLOOD-PRESSURE IN THE NUCLEUS TRACTUS SOLITARII OF THE RAT [J].

KUBO, T ;

MISU, Y .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1981, 317 (02) :120-125

← 1 2 →