GENE FOR THE CATALYTIC SUBUNIT OF MOUSE DNA-DEPENDENT PROTEIN-KINASE MAPS TO THE SCID LOCUS

被引：53

作者：

MILLER, RD

HOGG, J

OZAKI, JH

GELL, D

JACKSON, SP

RIBLET, R

机构：

[1] MED BIOL INST,LA JOLLA,CA 92037

[2] UNIV CAMBRIDGE,WELLCOME CANC RES CAMPAIGN INST,CAMBRIDGE CB2 1QR,ENGLAND

[3] UNIV CAMBRIDGE,DEPT ZOOL,CAMBRIDGE CB2 1QR,ENGLAND

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1995年 / 92卷 / 23期

基金：

英国惠康基金;

关键词：

D O I：

10.1073/pnas.92.23.10792

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The gene encoding the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) has been proposed recently as a candidate gene for the mouse severe combined immune deficiency (scid) locus, We have used a partial cDNA clone for human DNA-PKcs to map the mouse homologue using a large interspecific backcross panel, We found that the mouse gene for DNA-PKcs does not recombine with scid, consistent with the hypothesis that scid is a mutation in the mouse gene for DNA-PKcs.

引用

页码：10792 / 10795

页数：4