RETINOIC ACID AND INTERFERON COMBINATION STUDIES IN HUMAN CANCER

被引：44

作者：

LIPPMAN, SM

GLISSON, BS

KAVANAGH, JJ

LOTAN, R

HONG, WK

PAREDESESPINOZA, M

HITTELMAN, WN

HOLDENER, EE

KRAKOFF, IH

机构：

[1] UNIV TEXAS,M D ANDERSON CANC CTR,DIV MED,DEPT GYNECOL,HOUSTON,TX 77030

[2] UNIV TEXAS,M D ANDERSON CANC CTR,DIV MED,DEPT TUMOR BIOL,HOUSTON,TX 77030

[3] F HOFFMANN LA ROCHE & CO LTD,CH-4002 BASEL,SWITZERLAND

[4] F HOFFMANN LA ROCHE & CO LTD,CH-4002 BASEL,SWITZERLAND

[5] HOSP CIVIL GUADALAJARA,DEPT MED,MEXICO CITY,MEXICO

[6] INST JALISCI CANCEROL,GUADALAJARA,MEXICO

来源：

EUROPEAN JOURNAL OF CANCER | 1993年 / 29A卷

关键词：

D O I：

10.1016/0959-8049(93)90618-P

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Retinoic acid and interferon-alpha have limited single-agent activity in advanced cancer. Cell culture data indicate that in combination these agents have enhanced activity (modulating growth and differentiation) in a number of malignant cell types. Recent clinical work in advanced squamous cell carcinoma reports major activity with this regimen. This paper reviews the preclinical and clinical data testing retinoic acid in combination with interferons and presents recent work integrating these agents with radiotherapy in locally advanced cervical cancer.

引用

页码：S9 / S13

页数：5

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