STRIATAL EXPRESSION OF SUBSTANCE-P AND METHIONIN-ENKEPHALIN GENES IN PATIENTS WITH PARKINSONS-DISEASE

被引：24

作者：

LEVY, R

VILA, M

HERRERO, MT

FAUCHEUX, B

AGID, Y

HIRSCH, EC

机构：

[1] HOP LA PITIE SALPETRIERE,INSERM,U289,F-75651 PARIS 13,FRANCE

[2] UNIV MURCIA,DEPT ANAT,MURCIA,SPAIN

来源：

NEUROSCIENCE LETTERS | 1995年 / 199卷 / 03期

关键词：

SUBSTANCE P; METHIONIN-ENKEPHALIN; MESSENGER-RNA; IN SITU HYBRIDIZATION; STRIATUM; HUMAN; PARKINSONS DISEASE;

D O I：

10.1016/0304-3940(95)12011-R

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The striatal expression of substance P (SP) and methionin-enkephalin (met-enk) genes was studied post mortem by in situ hybridization in patients with Parkinson's disease and a group of control subjects. No significant difference in striatal expression of these two neuropeptide messenger RNAs (mRNAs) was found in the patients compared with control subjects. This contrasts with animal models of parkinsonism, where expression of SP mRNA is decreased and met-enk mRNA increased. Possible explanations include: (1) compensatory mechanisms, which may develop during the long term evolution of Parkinson's disease; (2) normalized expression of the two genes resulting from chronic L-DOPA therapy.

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页码：220 / 224

页数：5

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