RISKS AND BENEFITS OF DRUGS USED IN THE MANAGEMENT AND PREVENTION OF GOUT

被引：25

作者：

CONAGHAN, PG ^{[1
]}

DAY, RO ^{[1
]}

机构：

[1] ST VINCENTS HOSP,DEPT MED,SYDNEY,NSW 2010,AUSTRALIA

来源：

DRUG SAFETY | 1994年 / 11卷 / 04期

关键词：

D O I：

10.2165/00002018-199411040-00004

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 [公共卫生与预防医学]; 120402 [社会医学与卫生事业管理];

摘要：

Nonsteroidal anti-inflammatory drugs (NSAIDs) are now commonly used for the treatment of acute gout, but caution is required in view of their adverse effects, especially in the elderly. Colchicine is still an effective acute agent, but care must be taken to monitor toxicity. Intra-articular glucocorticosteroid therapy is useful and very safe; oral steroids and corticotrophin (adrenocorticotrophic hormone) may have a small role in acute therapy and seem safe when used over short time spans. Low dose colchicine may have a cost and toxicity advantage over NSAIDs in the prophylaxis of gout when commencing therapy aimed at reducing elevated plasma urate concentrations. Allopurinol is more frequently used than uricosuric agents such as probenecid, and toxicity may be largely avoided by tailoring dosage schedules according to renal function.

引用

页码：252 / 258

页数：7

共 44 条

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