CYTOKINE INDUCTION DURING CARDIAC-SURGERY - ANALYSIS OF TNF-ALPHA EXPRESSION PRECARDIOPULMONARY AND POSTCARDIOPULMONARY BYPASS

被引：19

作者：

HATTLER, BG

ZEEVI, A

ODDIS, CV

FINKEL, MS

机构：

[1] Departments of Surgery, University of Pittsburgh Medical Center, Pittsburg, Pennsylvania

[2] Departments of Medicine and Pathology, University of Pittsburgh Medical Center, Pittsburg, Pennsylvania

[3] Departments of Medicine and Pharmacology, University of Pittsburgh Medical Center, Pittsburg, Pennsylvania

来源：

JOURNAL OF CARDIAC SURGERY | 1995年 / 10卷 / 04期

关键词：

D O I：

10.1111/j.1540-8191.1995.tb00671.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cytokines are soluble mediators that possess both intra- and intercellular signaling properties. Their function has been investigated most thoroughly in the context of immune reactions. Cytokines, however, form an important component of the inflammatory response to trauma and are found in elevated concentrations following cardiopulmonary bypass (CPB), We were, therefore, interested in studying mRNA expression for the cytokine tumor necrosis factor alpha (TNF-alpha) in patients undergoing cardiac surgery, White cells isolated from the circulation of seven patients before and after CPB were assayed for the expression of mRNA with TNF-alpha specific primers using the polymerase chain reaction, Message for TNF-alpha was found in all patients, with the highest values demonstrated in patients whose CPB times exceeded 1 1/2 hours, Enhanced message expression was seen as early as 1 hour after the start of CPB, Genes responsible for cytokine (TNF-alpha) expression and production are activated during cardiac surgery,

引用

页码：418 / 422

页数：5

共 30 条

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