ENHANCED DEPLETION OF GLUTATHIONE AND INCREASED LIVER OXIDATIVE DAMAGE IN AFLATOXIN-FED MICE INFECTED WITH PLASMODIUM-BERGHEI

被引：6

作者：

ANKRAH, NA ^{[1
]}

SITTIE, A ^{[1
]}

ADDO, PGA ^{[1
]}

EKUBAN, FA ^{[1
]}

机构：

[1] CTR SCI RES PLANT MED,MAMPONG AKWAPIM,GHANA

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 1995年 / 89卷 / 01期

关键词：

MALARIA; PLASMODIUM BERGHEI; AFLATOXIN; GLUTATHIONE DEPLETION; LIVER DAMAGE;

D O I：

10.1016/0035-9203(95)90659-2

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

The effect of dietary aflatoxins B-1 and G(1) and Plasmodium berghei infection on glutathione (GSH) levels and liver status in mice was investigated. Three days after intraperitoneal injection of 0.1 x 10(6) parasitized red blood cells into the mice, there was a significant fall in blood glutathione levels accompanied by a significant increase in serum cholinesterase and liver malonic dialdehyde levels in the mice fed aflatoxin compared with those in the control group. The results suggested that malaria parasites can enhance depletion of host glutathione and oxidative damage of the liver in mice fed low levels of aflatoxins.

引用

页码：59 / 61

页数：3

共 16 条

[1] AFLATOXIN EXPOSURE, MALARIA AND HEPATITIS-B INFECTION IN RURAL GAMBIAN CHILDREN [J].