SYNTHESIS AND INVIVO ACTIVITY OF SOME PORPHYRINDIONE DERIVATIVES WITH POTENTIAL IN PHOTODYNAMIC THERAPY

被引：10

作者：

MORGAN, AR

GARBO, GM

KECK, RW

SKALKOS, D

SELMAN, SH

机构：

[1] UNIV TOLEDO,DEPT BIOL,TOLEDO,OH 43606

[2] UNIV TOLEDO,DEPT MED CHEM,TOLEDO,OH 43606

[3] MED COLL OHIO,DEPT SURG,TOLEDO,OH 43699

来源：

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY | 1990年 / 6卷 / 1-2期

关键词：

animal tumors; Bacteriochlorins; bladder tumors; photodynamic therapy; porphyrindiones;

D O I：

10.1016/1011-1344(90)85082-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A number of synthetic bacteriochlorins were prepared from porphyrindiones. The potential of these compounds as sensitizers for photodynamic therapy was examined using the FANFT-induced urothelial cell carcinoma (AY-27) transplanted into rats. In a number of cases, tumor regression was significant following treatment with both drug and light. © 1990.

引用

页码：133 / 141

页数：9

共 22 条

[1] MODELS OF PHOTOSYNTHETIC CHROMOPHORES - MOLECULAR-STRUCTURE AND AGGREGATION OF A BACTERIOCHLORIN
BARKIGIA, KM
FAJER, J
CHANG, CK
YOUNG, R
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1984, 106 (21) : 6457 - 6459
[2] PHOTOSENSITIZING PROPERTIES OF BACTERIOCHLOROPHYLLIN-A AND BACTERIOCHLORIN-A, 2 DERIVATIVES OF BACTERIOCHLOROPHYLL-A
BEEMS, EM
DUBBELMAN, TMAR
LUGTENBURG, J
VANBEST, JA
SMEETS, MFMA
BOEGHEIM, JPJ
[J]. PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1987, 46 (05) : 639 - 643
[3] HYDROPORPHYRINS OF THE MESO-TETRA(HYDROXYPHENYL)PORPHYRIN SERIES AS TUMOR PHOTOSENSITIZERS
BONNETT, R
WHITE, RD
WINFIELD, UJ
BERENBAUM, MC
[J]. BIOCHEMICAL JOURNAL, 1989, 261 (01) : 277 - 280
[4] CALLOT HJ, 1972, TETRAHEDRON LETT, V11, P1011
[5] DIELS-ALDER REACTIONS OF PROTOPORPHYRIN DIMETHYL ESTERS WITH NITROSOBENZENES - A NOVEL DEGRADATION TO FORMYL PORPHYRINS
CAVALEIRO, JAS
JACKSON, AH
NEVES, MGPMS
RAO, KRN
[J]. JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1985, (12) : 776 - 777
[6] A NOVEL METHOD OF FUNCTIONALIZING THE ETHYL CHAIN OF OCTAETHYLPORPHYRIN
CHANG, CK
SOTIRIOU, C
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1987, 52 (05) : 926 - 929
[7] MIGRATORY APTITUDES IN PINACOL REARRANGEMENT OF VIC-DIHYDROXYCHLORINS
CHANG, CK
SOTIRIOU, C
[J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 1985, 22 (06) : 1739 - 1741
[8] CHANG CK, 1984, J AM CHEM SOC, V106, P3943
[9] STUDIES ON THE STRUCTURE OF PORPHYRINS CONTAINED IN PHOTOFRIN-II
DOUGHERTY, TJ
[J]. PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1987, 46 (05) : 569 - 573
[10] MECHANISMS OF PHOTOSENSITIZATION
GIROTTI, AW
[J]. PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1983, 38 (06) : 745 - 751

← 1 2 3 →