CREATOL (5-HYDROXYCREATININE), A NEW TOXIN CANDIDATE IN UREMIC PATIENTS

被引：37

作者：

NAKAMURA, K ^{[1
]}

IENAGA, K ^{[1
]}

机构：

[1] NIPPON ZOKI PHARMACEUT CO LTD,INST BIOACT SCI,DEPT NAT PROD CHEM,HYOGO 67314,JAPAN

来源：

EXPERIENTIA | 1990年 / 46卷 / 05期

关键词：

5-hydroxy-1-methylhydantoin; 5-hydroxycreatinine; Creatinine; creatol; uremia; uremic toxin;

D O I：

10.1007/BF01954234

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Both 5-hydroxy-1-methylhydantoin (3) and the hitherto unrecognized 5-hydroxycreatinine (2-amino-5-hydroxy-1-methyl-imidazol-4(5 H)-one or creatol) (6) can be isolated from the urine of uremic patients, in whom these compounds probably arise as oxidative metabolites of creatinine (1). The enhanced production of the well-known uremic toxin, methylguanidine (8), from creatinine (1) in such patients, almost certainly occurs via the newly recognized metabolite (6). © 1990 Birkhäuser Verlag.

引用

页码：470 / 472

页数：3

共 12 条

[1]

AOYAGI K, 1987, KIDNEY INT, V22, P229

[2] EVIDENCE OF RED-BLOOD-CELL MEMBRANE LIPID-PEROXIDATION IN HEMODIALYSIS-PATIENTS [J].

GIARDINI, O ;

TACCONEGALLUCCI, M ;

LUBRANO, R ;

RICCIARDITENORE, G ;

BANDINO, D ;

SILVI, I ;

RUBERTO, U ;

CASCIANI, CU .

NEPHRON, 1984, 36 (04) :235-237

[3] METHYLGUANIDINE IN UREMIA [J].

GIOVANNETTI, S ;

BALESTRI, PL ;

BARSOTTI, G .

ARCHIVES OF INTERNAL MEDICINE, 1973, 131 (05) :709-713

[4]

GIOVANNETTI S, 1969, CLIN SCI, V36, P445

[5] THE STEPWISE MAMMALIAN OXIDATION OF THE HYDANTOIN 1-METHYLIMIDAZOLIDINE-2,4-DIONE INTO METHYLIMIDAZOLIDINETRIONE VIA 5-HYDROXY-1-METHYL-IMIDAZOLIDINE-2,4-DIONE [J].

IENAGA, K ;

NAKAMURA, K ;

ISHII, A ;

TAGA, T ;

MIWA, Y ;

YONEDA, F .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1989, (06) :1153-1156

[6] BIOACTIVE COMPOUNDS PRODUCED IN ANIMAL-TISSUES .2. HYDANTOIN PLANT-GROWTH REGULATORS ISOLATED FROM INFLAMED RABBIT SKIN TISSUE [J].

IENAGA, K ;

NAKAMURA, K ;

GOTO, T ;

KONISHIA, J .

TETRAHEDRON LETTERS, 1987, 28 (39) :4587-4588

[7] THE METABOLISM OF 1-METHYLHYDANTOIN VIA 5-HYDROXY-1-METHYLHYDANTOIN IN MAMMALS [J].

IENAGA, K ;

NAKAMURA, K ;

NAKA, F ;

GOTO, T .

BIOCHIMICA ET BIOPHYSICA ACTA, 1988, 967 (03) :441-443

[8]

JONES JD, 1975, KIDNEY INT, V7, P294

[9] BIOSYNTHESIS OF METHYLGUANIDINE IN ISOLATED RAT HEPATOCYTES AND INVIVO [J].

NAGASE, S ;

AOYAGI, K ;

NARITA, M ;

TOJO, S .

NEPHRON, 1985, 40 (04) :470-475

[10] BACTERIAL DEGRADATION OF CREATININE .2. CREATININE DESIMIDASE [J].

SZULMAJSTER, J .

BIOCHIMICA ET BIOPHYSICA ACTA, 1958, 30 (01) :154-163

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