EFFECTS OF EPINEPHRINE ON THE NET HEPATIC-UPTAKE OF LACTATE, PYRUVATE, AND GLYCEROL IN SHEEP

被引:6
作者
BROCKMAN, RP
机构
[1] Dept. of Animal/Poultry Sci., University of Saskatchewan, Saskatchewon, Sask.
关键词
EPINEPHRINE; HEPATIC GLUCONEOGENESIS; SHEEP;
D O I
10.1139/y91-071
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Epinephrine causes hyperglycemia in part by increasing gluconeogenesis. However, the mechanism of its gluconeogenic effects has not been studied in ruminants. This study was undertaken to examine the effect of epinephrine on the net hepatic uptake of selected glucose precursors in sheep. The major abdominal blood vessels of the sheep were catheterized in normal and alloxan diabetic sheep. Glucose production, metabolic clearance of glucose, and the hepatic removal of certain glucose precursors were determined before, during, and after epinephrine infusion. Epinephrine increased the hepatic glucose output, the concentrations of lactate and glycerol in plasma, and the net hepatic uptake and fractional hepatic extraction of lactate and glycerol. These effects were independent of changes in the concentrations of insulin and glucagon in plasma. These results show that epinephrine directly stimulates hepatic gluconeogenesis in sheep.
引用
收藏
页码:475 / 479
页数:5
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