THE POLYMORPHIC SUBTELOMERIC REGIONS OF PLASMODIUM-FALCIPARUM CHROMOSOMES CONTAIN ARRAYS OF REPETITIVE SEQUENCE ELEMENTS

被引：69

作者：

DEBRUIN, D ^{[1
]}

LANZER, M ^{[1
]}

RAVETCH, JV ^{[1
]}

机构：

[1] SLOAN KETTERING INST,DIV MOLEC BIOL,DEWITT WALLACE RES LAB,NEW YORK,NY 10021

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1994年 / 91卷 / 02期

关键词：

MALARIA; RECOMBINATION; GENOME ORGANIZATION;

D O I：

10.1073/pnas.91.2.619

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The human malaria parasite Plasmodium falciparum exhibits a high degree of chromosomal polymorphism, which may contribute to its ability to evade host defenses. The analysis of parasite chromosomes has revealed that these poly morphisms are confined to the subtelomeric regions, which are transcriptionally silent and contain repetitive sequence elements. Several subtelomeric repetitive elements have been isolated and mapped by using P. falciparum yeast artificial chromosome (YAC) clones. Structural analysis of parasite telomeric and subtelomeric YAC clones demonstrated that these repetitive elements are conserved between P. falciparum chromosome ends. We suggest that these subtelomeric elements promote chromosome pairing in P. falciparum and facilitate meiotic recombination and gene conversion between telomere-proximal genes.

引用

页码：619 / 623

页数：5

共 33 条

[1] GENETICS AND MOLECULAR-BIOLOGY OF TELOMERES
BIESSMANN, H
MASON, JM
[J]. ADVANCES IN GENETICS, 1992, 30 : 185 - 249
[2] SUBTELOMERIC CHROMOSOME DELETIONS IN FIELD ISOLATES OF PLASMODIUM-FALCIPARUM AND THEIR RELATIONSHIP TO LOSS OF CYTOADHERENCE INVITRO
BIGGS, BA
KEMP, DJ
BROWN, GV
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (07) : 2428 - 2432
[3] STRUCTURE AND POLYMORPHISM OF HUMAN TELOMERE-ASSOCIATED DNA
BROWN, WRA
MACKINNON, PJ
VILLASANTE, A
SPURR, N
BUCKLE, VJ
DOBSON, MJ
[J]. CELL, 1990, 63 (01) : 119 - 132
[4] CLONING AND ANALYSIS OF THE RESA-2 GENE - A DNA HOMOLOG OF THE RING-INFECTED ERYTHROCYTE SURFACE-ANTIGEN GENE OF PLASMODIUM-FALCIPARUM
CAPPAI, R
KASLOW, DC
PETERSON, MG
COWMAN, AF
ANDERS, RF
KEMP, DJ
[J]. MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1992, 54 (02) : 213 - 222
[5] CARLSON M, 1985, MOL CELL BIOL, V5, P3584
[6] HOMOLOGOUS RECOMBINATION WITHIN SUBTELOMERIC REPEAT SEQUENCES GENERATES CHROMOSOME SIZE POLYMORPHISMS IN P-FALCIPARUM
CORCORAN, LM
THOMPSON, JK
WALLIKER, D
KEMP, DJ
[J]. CELL, 1988, 53 (05) : 807 - 813
[7] CHROMOSOME SIZE POLYMORPHISMS IN PLASMODIUM-FALCIPARUM CAN INVOLVE DELETIONS AND ARE FREQUENT IN NATURAL PARASITE POPULATIONS
CORCORAN, LM
FORSYTH, KP
BIANCO, AE
BROWN, GV
KEMP, DJ
[J]. CELL, 1986, 44 (01) : 87 - 95
[8] CHARACTERIZATION OF YEAST ARTIFICIAL CHROMOSOMES FROM PLASMODIUM-FALCIPARUM - CONSTRUCTION OF A STABLE, REPRESENTATIVE LIBRARY AND CLONING OF TELOMERIC DNA FRAGMENTS
DEBRUIN, D
LANZER, M
RAVETCH, JV
[J]. GENOMICS, 1992, 14 (02) : 332 - 339
[9] CHROMOSOMES OF MALARIA PARASITES
FOOTE, SJ
KEMP, DJ
[J]. TRENDS IN GENETICS, 1989, 5 (10) : 337 - 342
[10] POSITION EFFECT AT SACCHAROMYCES-CEREVISIAE TELOMERES - REVERSIBLE REPRESSION OF POL-II TRANSCRIPTION
GOTTSCHLING, DE
APARICIO, OM
BILLINGTON, BL
ZAKIAN, VA
[J]. CELL, 1990, 63 (04) : 751 - 762

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