FELINE CD4 MOLECULES EXPRESSED ON FELINE NONLYMPHOID CELL-LINES ARE NOT ENOUGH FOR PRODUCTIVE INFECTION OF HIGHLY LYMPHOTROPIC FELINE IMMUNODEFICIENCY VIRUS ISOLATES

被引：28

作者：

NORIMINE, J ^{[1
]}

MIYAZAWA, T ^{[1
]}

KAWAGUCHI, Y ^{[1
]}

TOMONAGA, K ^{[1
]}

SHIN, YS ^{[1
]}

TOYOSAKI, T ^{[1
]}

KOHMOTO, M ^{[1
]}

NIIKURA, M ^{[1
]}

TOHYA, Y ^{[1
]}

MIKAMI, T ^{[1
]}

机构：

[1] UNIV TOKYO,FAC AGR,DEPT VET MICROBIOL,1-1-1 YAYOI,BUNKYO KU,TOKYO 113,JAPAN

来源：

ARCHIVES OF VIROLOGY | 1993年 / 130卷 / 1-2期

关键词：

D O I：

10.1007/BF01319005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

To investigate whether the feline CD 4 (fCD 4) molecules are involved in infections of highly lymphotropic feline immunodeficiency virus (FIV) isolates, we expressed fCD 4 stably on Crandell feline kidney cells and Felis catus whole foetus 4 cells by transfection of a cDNA encoding the fCD 4 glycoprotein, and then infected them with TM 1 and TM 2 strains of FIV, which are unable to infect these cells productively. In spite of fCD 4 being expressed on these cells, no virus production was observed. This result indicates that fCD 4 expression alone cannot induce a productive infection of the FIV TM 1 and TM 2 strains.

引用

页码：171 / 178

页数：8

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