BCR-ABL REARRANGEMENT AND VARIANT PHILADELPHIA-CHROMOSOME IN DE-NOVO ACUTE MYELOGENOUS LEUKEMIA FAB SUBTYPE M1

被引：5

作者：

CIGUDOSA, JC ^{[1
]}

ALMEIDA, MTA ^{[1
]}

CARRASCO, V ^{[1
]}

BELLO, T ^{[1
]}

CARRASCO, JL ^{[1
]}

GOMEZ, AO ^{[1
]}

GARCIA, J ^{[1
]}

TALAVERA, JG ^{[1
]}

MIRANDA, JLG ^{[1
]}

机构：

[1] HOSP N SRA LA CANDELARIA,SERV HAEMATOL,TENERIFE,SPAIN

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1995年 / 91卷 / 04期

关键词：

LEUKEMIA; CHROMOSOMES; TRANSLOCATION; BCR-ABL; REARRANGEMENT;

D O I：

10.1111/j.1365-2141.1995.tb05414.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report a case of de novo acute myelogenous leukaemia FAB subtype M1 that presents a cytogenetic complex translocation between chromosomes 7, 9 and 22, producing a 'variant' Philadelphia chromosome, Molecular analysis revealed a BCR-ABL rearrangement involving exons b3 and a2 (b3a2). Haematological parameters and genetic analysis again raise the problem of the true nature of this disease, which is briefly discussed.

引用

页码：932 / 934

页数：3

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