CONGENITAL-MALFORMATIONS IN OFFSPRING OF DIABETIC WOMEN TREATED WITH ORAL HYPOGLYCEMIC AGENTS DURING EMBRYOGENESIS

A markedly increased risk (50 %) of congenital malformations in the offspring of women treated with oral hypoglycaemic agents during the first trimester has recently been reported. With this background, the medical records of a consecutive sample of 25 pregnant Type 2 diabetic women treated with oral hypoglycaemic agents during embryogenesis between 1966 and 1991 in the diabetic service of a university hospital, were studied retrospectively. None of the infants had major congenital malformations disclosed in the neonatal period (0 %, 97.5 % confidence interval 0.0-13.7 %), but one minor congenital malformation was found (4.0 %, 95 % confidence interval 0.1-20.3 %). Although this study, due to the limited number of pregnancies examined, does not exclude an association between treatment with oral hypoglycaemic agents at the time of embryogenesis and major congenital malformations in the offspring, the previously reported association was not confirmed. Thus we find no obvious indication for therapeutic abortions in patients who have accidentally been treated with oral hypoglycaemic agents during embryogenesis. On the contrary it seems reasonable to reassure these women with respect to their risk of having a malformed baby, stop the treatment with oral hypoglycaemic agents and initiate insulin treatment.