ANALYSIS OF LYMPHOCYTE COSTIMULATION IN-VIVO USING TRANSGENIC AND KNOCKOUT MICE

被引：72

作者：

SHARPE, AH ^{[1
]}

机构：

[1] HARVARD UNIV,SCH MED,BOSTON,MA 02115

来源：

CURRENT OPINION IN IMMUNOLOGY | 1995年 / 7卷 / 03期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0952-7915(95)80115-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The use of transgenic technologies in the functional evaluation of the contributions of costimulatory pathways to T-cell activation in vivo has recently undergone a rapid expansion. During the past two years, mice deficient in costimulatory molecules and their receptors have been generated. These mice have revealed novel and critical in vivo functions of costimulatory pathways and have provided valuable models in which to test therapeutic strategies involving costimulatory pathway blockade. Transgenic mice constitutively expressing costimulatory molecules have provided insights into their role in peripheral tolerance.

引用

页码：389 / 395

页数：7

共 54 条

[1]

Linsley, Ledbetter, The role of the CD28 receptor during T cell responses to antigen, Annu Rev Immunol, 11, pp. 191-212, (1993)

[2]

Jenkins, Johnson, Molecules involved in T-cell costimulation, Curr Opin Immunol, 5, pp. 361-367, (1993)

[3]

Schwartz, A cell culture model for T lymphocyte clonal anergy, Science, 248, pp. 1349-1356, (1990)

[4]

Clark, Ledbetter, How B and T cells talk to each other, Nature, 367, pp. 425-428, (1994)

[5]

Boussiotis, Freeman, Gray, Gribben, Nadler, B7 but not ICAM-1 costimulation prevents the induction of human alloantigen specific tolerance, J Exp Med, 178, pp. 1753-1763, (1993)

[6]

Bullard, Sandberg, Scharffetter-Kochanek, Beaudet, Gene targeting for inflammatory cell adhesion molecules, Inflamm Res, (1995)

[7]

Boussiotis, Gribben, Freeman, Nadler, Blockade of the CD28 costimulatory pathway: a means to induce tolerance, Curr Opin Immunol, 6, pp. 797-807, (1994)

[8]

Bradley, Teratocarcinomas and Embryonic Stem Cells: A Practical Approach, (1987)

[9]

Sedivy, Joyner, Gene Targeting, (1992)

[10]

Xu, Gonzalo, St. Pierre, Williams, Kupper, Cotran, Springer, Gutierrez-Ramos, Leukocytosis and resistance to septic shock in intercellular adhesiion molecule 1-deficient mice, J Exp Med, 180, pp. 95-109, (1994)

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