THE ACTIVITY OF CANDIDATE VIRUCIDAL AGENTS, LOW PH AND GENITAL SECRETIONS AGAINST HIV-1 IN-VITRO

被引：67

作者：

OCONNOR, TJ

KINCHINGTON, D

KANGRO, HO

JEFFRIES, DJ

机构：

[1] Department of Virology, Medical College of St Bartholomew's Hospital, London

来源：

INTERNATIONAL JOURNAL OF STD & AIDS | 1995年 / 6卷 / 04期

关键词：

HIV; SPERMICIDES; VIRUCIDES; VIRAL STABILITY; SEMEN; CERVICAL MUCUS;

D O I：

10.1177/095646249500600409

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The effect of low pH, normally present in the female genital tract, on HIV visibility was examined. HIV is more acid stable than previously reported with no substantial reduction in infectivity occurring until pH levels are reduced below 4.5. The virucidal activity of 3 topical spermicides and chlorhexidine was assessed in vitro using previously established and newly modified assay systems. None of the agents tested had a selectivity index (SI) greater than 5.2. Semen and cervical secretions were assessed for their ability to inhibit HIV-1. While no virucidal effect was found in the latter, seminal fluid was found to have significant activity against HIV-1 and a SI approximately 50.

引用

页码：267 / 272

页数：6

共 28 条

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