QUATERNARY STRUCTURE OF THE ACETYLCHOLINE-RECEPTOR

被引：234

作者：

BRISSON, A ^{[1
]}

UNWIN, PNT ^{[1
]}

机构：

[1] STANFORD UNIV, MED CTR, SCH MED, DEPT CELL BIOL, STANFORD, CA 94305 USA

来源：

NATURE | 1985年 / 315卷 / 6019期

关键词：

D O I：

10.1038/315474a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The 5 membrane-spanning subunits of the acetylcholine receptor [from Torpedo marmorata] were resolved in electron microscopic images and were shown to lie at pentagonally symmetrical positions around the channel over a large fraction of their length. The channel consists of a wide synaptic portion and a narrow portion extending through the membrane into the interior of the cell.

引用

页码：474 / 477

页数：4

共 28 条

[1] A LEAST-SQUARES METHOD FOR DETERMINING STRUCTURE FACTORS IN 3-DIMENSIONAL TILTED-VIEW RECONSTRUCTIONS [J].

AGARD, DA .

JOURNAL OF MOLECULAR BIOLOGY, 1983, 167 (04) :849-852

[2] 3-DIMENSIONAL STRUCTURE DETERMINATION BY ELECTRON-MICROSCOPY OF TWO-DIMENSIONAL CRYSTALS [J].

AMOS, LA ;

HENDERSON, R ;

UNWIN, PNT .

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 1983, 39 (03) :183-231

[3] IMAGE-ANALYSIS OF THE HEAVY FORM OF THE ACETYLCHOLINE-RECEPTOR FROM TORPEDO-MARMORATA [J].

BON, F ;

LEBRUN, E ;

GOMEL, J ;

VANRAPENBUSCH, R ;

CARTAUD, J ;

POPOT, JL ;

CHANGEUX, JP .

JOURNAL OF MOLECULAR BIOLOGY, 1984, 176 (02) :205-237

[4] TUBULAR CRYSTALS OF ACETYLCHOLINE-RECEPTOR [J].

BRISSON, A ;

UNWIN, PNT .

JOURNAL OF CELL BIOLOGY, 1984, 99 (04) :1202-1211

[5]

CARTAUD J, 1978, J CELL SCI, V29, P313

[6]

CHANGEUX JP, 1981, HARVEY LECT, V75, P85

[7] NUCLEOTIDE AND DEDUCED AMINO-ACID-SEQUENCES OF TORPEDO-CALIFORNICA ACETYLCHOLINE-RECEPTOR GAMMA-SUBUNIT [J].

CLAUDIO, T ;

BALLIVET, M ;

PATRICK, J ;

HEINEMANN, S .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (04) :1111-1115

[8]

CONTITRONCONI BM, 1982, ANNU REV BIOCHEM, V51, P491, DOI 10.1146/annurev.bi.51.070182.002423

[9] EVIDENCE FOR UNPREDICTED TRANSMEMBRANE DOMAINS IN ACETYLCHOLINE-RECEPTOR SUBUNITS [J].

CRIADO, M ;

HOCHSCHWENDER, S ;

SARIN, V ;

FOX, JL ;

LINDSTROM, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (07) :2004-2008

[10] COMPLETE MESSENGER-RNA CODING SEQUENCE OF THE ACETYLCHOLINE BINDING ALPHA-SUBUNIT OF TORPEDO-MARMORATA ACETYLCHOLINE-RECEPTOR - A MODEL FOR THE TRANSMEMBRANE ORGANIZATION OF THE POLYPEPTIDE-CHAIN [J].

DEVILLERSTHIERY, A ;

GIRAUDAT, J ;

BENTABOULET, M ;

CHANGEUX, JP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (07) :2067-2071

← 1 2 3 →