THE CONTRIBUTION OF THE DIFFERENT BINDING-SITES OF THE N-METHYL-D-ASPARTATE (NMDA) RECEPTOR TO THE EXPRESSION OF BEHAVIOR

被引：63

作者：

KRETSCHMER, BD

ZADOW, B

VOLZ, TL

VOLZ, L

SCHMIDT, WJ

机构：

[1] Department of Neuropharmacology, Zoological Institute, University of Tübingen

来源：

JOURNAL OF NEURAL TRANSMISSION-GENERAL SECTION | 1992年 / 87卷 / 01期

关键词：

NMDA RECEPTOR; LOCOMOTION; CATALEPSY; STEREOTYPY; RAT; CGP37849; DIZOCILPINE (MK-801); GLYCINE; D-CYCLOSERINE;

D O I：

10.1007/BF01253108

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of competitive (CGP37849 and CGP39551) and noncompetitive (dizocilpine) N-methyl-D-aspartate (NMDA) antagonists were tested in three animal models (catalepsy, sniffing, locomotion) and, in addition, the modulation of these effects by an agonist of the strychnine-insensitive glycine binding site was investigated. Both competitive and non-competitive NMDA antagonists reduced neuroleptic-induced catalepsy. Weak sniffing was induced by the competitive antagonist but strong sniffing by the non-competitive NMDA antagonist. Due to muscle relaxation the competitive antagonist reduced locomotion, in contrast to stimulation of locomotor activity induced by the noncompetitive NMDA antagonist. The glycine agonist (D-cycloserine) potentiated the effects of the non-competitive but antagonized those of the competitive NMDA antagonist.

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页码：23 / 35

页数：13

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