INTERLEUKIN-6 - EFFECTS ON AND PRODUCTION BY RAT GRANULOSA-CELLS INVITRO

被引：119

作者：

GOROSPE, WC ^{[1
]}

HUGHES, FM ^{[1
]}

SPANGELO, BL ^{[1
]}

机构：

[1] MED UNIV S CAROLINA,DEPT PHYSIOL,CHARLESTON,SC 29425

来源：

ENDOCRINOLOGY | 1992年 / 130卷 / 03期

关键词：

D O I：

10.1210/en.130.3.1750

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Treatment of FSH-stimulated granulosa cells with increasing amounts of interleukin-6 (IL-6) caused a significant concentration-dependent suppression of progesterone biosynthesis. However, basal progesterone production in non-FSH-stimulated cells remained unresponsive to the cytokine. Quantitation of IL-6 in the conditioned media from untreated granulosa cells by the 7TD1 hybridoma cell bioassay revealed detectable levels of IL-6. Further, FSH treatment caused a significant concentration-dependent increase in IL-6 release. In contrast, both basal and FSH-stimulated IL-6 release could be significantly suppressed by interferon gamma (INF-gamma). The results of the present study suggest: 1) a role for IL-6 in the regulation of progesterone production, 2) that the granulosa cell is a source of IL-6 and 3) that the release of IL-6 by the granulosa cell is a regulated event.

引用

页码：1750 / 1752

页数：3

共 22 条

[1] THE POTENTIAL RELEVANCE OF CYTOKINES TO OVARIAN PHYSIOLOGY - THE EMERGING ROLE OF RESIDENT OVARIAN-CELLS OF THE WHITE BLOOD-CELL SERIES [J].