CHEMICAL INDUCTION OF SOMATIC GENE-MUTATIONS AND CHROMOSOMAL-ABERRATIONS IN LUNG FIBROBLASTS OF RATS

被引：24

作者：

KHAN, MA ^{[1
]}

HEDDLE, JA ^{[1
]}

机构：

[1] YORK UNIV,DEPT BIOL,N YORK M3J 1P3,ONTARIO,CANADA

来源：

MUTATION RESEARCH | 1991年 / 263卷 / 04期

关键词：

MICRONUCLEI; GENE MUTATIONS; SOMATIC; LUNG FIBROBLASTS; FIBROBLASTS; LUNG; RAT; METHYL METHANESULFONATE; ETHYL NITROSOUREA;

D O I：

10.1016/0165-7992(91)90010-2

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Rats can be used to detect both somatic gene mutations and chromosomal aberrations induced in vivo. The technique adapted from Chinese hamsters for the isolation and analysis of lung fibroblasts confirm the surprising results obtained in hamsters; namely, methyl methanesulphonate induces many micronuclei but no significant increase in gene mutations. In contrast ethylnitrosourea induces both micronuclei and gene mutations.

引用

页码：257 / 262

页数：6

共 19 条

[1]

DEAN BJ, 1977, DETECTION CHEM INDUC

[2] DIFFERENTIAL MUTAGENICITY OF AMINE AND AMIDE DERIVATIVES OF NITROSO COMPOUNDS IN DROSOPHILA MELANOGASTER [J].

FAHMY, OG ;

FAHMY, MJ ;

MASSASSO, J ;

ONDREJ, M .

MUTATION RESEARCH, 1966, 3 (03) :201-&

[3] MEASUREMENT OF MICRONUCLEI IN LYMPHOCYTES [J].

FENECH, M ;

MORLEY, AA .

MUTATION RESEARCH, 1985, 147 (1-2) :29-36

[4]

HANSEN MF, 1987, CANCER RES, V47, P5518

[5] CONCURRENT DETECTION OF GENE-MUTATIONS AND CHROMOSOMAL-ABERRATIONS INDUCED INVIVO IN SOMATIC-CELLS [J].

HEDDLE, JA ;

BOUCH, A ;

KHAN, MA ;

GINGERICH, JD .

MUTAGENESIS, 1990, 5 (02) :179-184

[6] A METHOD TO QUANTIFY SPONTANEOUS AND INVIVO INDUCED THIOGUANINE-RESISTANT MOUSE LYMPHOCYTES [J].

JONES, IM ;

BURKHARTSCHULTZ, K ;

CARRANO, AV .

MUTATION RESEARCH, 1985, 147 (03) :97-105

[7]

KNUDSON AG, 1985, CANCER RES, V45, P1437

[8] CELLULAR ONCOGENES AND MULTISTEP CARCINOGENESIS [J].

LAND, H ;

PARADA, LF ;

WEINBERG, RA .

SCIENCE, 1983, 222 (4625) :771-778

[9]

LEGATOR MS, 1971, CHEMICAL MUTAGENS PR, V2, P569

[10]

MAIER P, 1983, CHEM MUTAGENS PRINCI, V8, P233

← 1 2 →