AN ANALOG OF MET-ENKEPHALIN ATTENUATES THE PITUITARY-ADRENAL RESPONSE TO OVINE CORTICOTROPIN RELEASING-FACTOR

被引:26
作者
GROSSMAN, A
DELITALA, G
MANNELLI, M
ALDAMLUJI, S
COY, DH
BESSER, GM
机构
[1] ST BARTHOLOMEWS HOSP, DEPT ENDOCRINOL, LONDON EC1A 7BE, ENGLAND
[2] UNIV FLORENCE, CHAIR ENDOCRINOL, I-50121 FLORENCE, ITALY
[3] TULANE UNIV, SCH MED, DEPT MED, NEW ORLEANS, LA 70112 USA
[4] UNIV SASSARI, DEPT ENDOCRINOL, I-07100 SASSARI, ITALY
关键词
D O I
10.1111/j.1365-2265.1986.tb01708.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The met-enkephalin analogue, DAMME, suppresses the pituitary-adrenal axis in normal subjects; it is not clear whether this occurs at the level of the pituitary or above. We therefore administered synthetic ovine corticotrophin releasing factor (CRF-41) 100 .mu.g i.v. to a group of normal male subjects, with or without pretreatment with DAMME 250 .mu.g i.v., and monitored the resposne of plasma ACTH and serum cortisol. CRF-41 caused a marked stimulation of ACTH and cortisol release, but this was significantly attenuated by pretreatment with DAMME. It is therefore concluded that DAMME either directly inhibits the corticotroph at the level of the pituitary, or that it suppresses release of an additional factor which normally potentiates the action of CRF-41 on the pituitary.
引用
收藏
页码:421 / 426
页数:6
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