EFFECT OF PHENCYCLIDINE ON DOPAMINE RELEASE IN THE RAT PREFRONTAL CORTEX - AN IN-VIVO MICRODIALYSIS STUDY

被引:120
作者
HONDO, H
YONEZAWA, Y
NAKAHARA, T
NAKAMURA, K
HIRANO, M
UCHIMURA, H
TASHIRO, N
机构
[1] KYUSHU UNIV, FAC SCI, DEPT CHEM, HIGASHI KU, FUKUOKA, FUKUOKA 812, JAPAN
[2] KYUSHU UNIV, FAC MED, DEPT NEUROPSYCHIAT, HIGASHI KU, FUKUOKA, FUKUOKA 812, JAPAN
关键词
PHENCYCLIDINE; MK-801; DOPAMINE; PREFRONTAL CORTEX; MICRODIALYSIS;
D O I
10.1016/0006-8993(94)91558-X
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The effect of phencyclidine (PCP) on the extracellular dopamine levels in the rat prefrontal cortex was investigated using an in vivo brain dialysis technique. PCP increased extracellular dopamine levels in the prefrontal cortex of freely-moving rats after the systemic (7.5 mg/kg i.p.) or the local injection (100 mu M and 500 mu M). The local injection of MK-801, which is a more selective and potent NMDA receptor antagonist than PCP also increased the extracellular dopamine levels (from 10 mu M to 100 mu M). These results suggest that part of the effect of PCP is attributable to its antagonistic effect on the NMDA receptor.
引用
收藏
页码:337 / 342
页数:6
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