PEDIATRIC CARBAMAZEPINE OVERDOSES

被引：14

作者：

BRIDGE, TA ^{[1
]}

NORTON, RL ^{[1
]}

ROBERTSON, WO ^{[1
]}

机构：

[1] OREGON HLTH SCI UNIV,DEPT PEDIAT,PORTLAND,OR 97201

来源：

PEDIATRIC EMERGENCY CARE | 1994年 / 10卷 / 05期

关键词：

CARBAMAZEPINE; OVERDOSE; TOXICITY; SEIZURE; COMA; INTUBATION;

D O I：

10.1097/00006565-199410000-00004

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Thirty pediatric cases of carbamazepine overdoses were reviewed retrospectively for the frequency of toxic effects. Patients were divided into three groups, depending on the type of overdose: acute, acute-on-chronic, and chronic. Effects included lethargy in 93%, ataxia in 50%, nystagmus in 13%, and minor arrhythmias in 10%. Major effects included seizures in 20%, coma in 27%, and need for intubation in 20%. Higher serum carbamazepine levels were associated with these major effects in the acute and acute-on-chronic groups but not in the chronic group. Serum levels greater than 35 mg/L (147 mumol/L), were significantly associated with major toxicities.

引用

页码：260 / 263

页数：4

共 29 条

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