BROAD-SPECTRUM ANTIVIRAL ACTIVITY OF CARBODINE, THE CARBOCYCLIC ANALOG OF CYTIDINE

被引：32

作者：

DECLERCQ, E ^{[1
]}

BERNAERTS, R ^{[1
]}

SHEALY, YF ^{[1
]}

MONTGOMERY, JA ^{[1
]}

机构：

[1] SO RES INST,KETTERING MEYER LAB,BIRMINGHAM,AL 35255

来源：

BIOCHEMICAL PHARMACOLOGY | 1990年 / 39卷 / 02期

关键词：

D O I：

10.1016/0006-2952(90)90031-F

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Carbocyclic cytidine (C-Cyd) is a broad-spectrum antiviral agent active against DNA viruses [pox (vaccinia)], (+)RNA viruses [toga (Sindbis, Semliki forest), corona], (-)RNA viruses [orthomyxo (influenza), paramyxo (parainfluenza, measles), rhabdo (vesicular stomatitis)] and (±)RNA viruses (reo). The target enzyme of C-Cyd is supposed to be CTP synthetase that converts UTP to CTP. In keeping with this assumption are the observations that (i) C-Cyd effects a dose-dependent inhibition of RNA synthesis in both virus-infected and uninfected cells, and (ii) exogenous addition of either Urd or Cyd reverses both the antiviral and cytocidal activity of C-Cyd, whereas addition of dThd or dCyd fails to do so. The selectivity of C-Cyd against Sindbis, vesicular stomatitis and reo virus is markedly increased when C-Cyd is combined with Cyd (10 μg/mL). This combination may therefore be worth pursuing as a chemotherapeutic modality for the treatment of virus infections. © 1989.

引用

页码：319 / 325

页数：7

共 33 条

[1] CORRELATION BETWEEN THE ANTIVIRAL ACTIVITY OF ACYCLIC AND CARBOCYCLIC ADENOSINE-ANALOGS IN MURINE L929 CELLS AND THEIR INHIBITORY EFFECT ON L929 CELL S-ADENOSYLHOMOCYSTEINE HYDROLASE [J].