DETERMINATION OF PLASMA-LEVELS OF BUPIVACAINE BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：10

作者：

RUZAFA, A

PASTOR, MC

AGUILAR, JL

GALIMANY, R

机构：

[1] Clinical Chemistry Laboratory, Hospital “Germans Trias Pujol”, 08916 Badalona, Barcelona, C. Canyet s/n.

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY | 1991年 / 14卷 / 15期

关键词：

D O I：

10.1080/01483919108049367

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We evaluate a method for determination of bupivacaine using HPLC, and the possibility of pharmacological interferences produced by seven commonly used drugs administered before, during and after surgery: diacepam, midazolam, epinephrine, naloxone, flumacenil, atropine and ephedrine. The method has an average recovery of 102.8 +/- 5.4 %. The detection limit is 0.125-mu-g/mL. The within-day coefficient of variation is 5.88 % and the between-day coefficient of variation is 15 %. We haven't found drug interferences at generally encountered serum concentrations.

引用

页码：2937 / 2949

页数：13

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