SOMATOSTATIN ANALOGS - RELATIVE IMPORTANCE OF DISULFIDE BRIDGE AND OF ALA-GLY SIDE-CHAIN FOR BIOLOGICAL-ACTIVITY

被引：61

作者：

RIVIER, J ^{[1
]}

BRAZEAU, P ^{[1
]}

VALE, W ^{[1
]}

GUILLEMIN, R ^{[1
]}

机构：

[1] SALK INST, NEUROENDOCRINOL LAB, LA JOLLA, CA 92037 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1975年 / 18卷 / 02期

关键词：

D O I：

10.1021/jm00236a001

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：123 / 126

页数：4

共 25 条

[1] INHIBITION OF GROWTH-HORMONE SECRETION IN RAT BY SYNTHETIC SOMATOSTATIN [J].

BRAZEAU, P ;

RIVIER, J ;

VALE, W ;

GUILLEMI.R .

ENDOCRINOLOGY, 1974, 94 (01) :184-187

[2] HYPOTHALAMIC POLYPEPTIDE THAT INHIBITS SECRETION OF IMMUNOREACTIVE PITUITARY GROWTH-HORMONE [J].

BRAZEAU, P ;

VALE, W ;

BURGUS, R ;

LING, N ;

BUTCHER, M ;

RIVIER, J ;

GUILLEMIN, R .

SCIENCE, 1973, 179 (4068) :77-79

[3] SOMATOSTATIN - NEWCOMER FROM HYPOTHALAMUS [J].

BRAZEAU, P ;

GUILLEMI.R .

NEW ENGLAND JOURNAL OF MEDICINE, 1974, 290 (17) :963-964

[4] BIOLOGICAL POTENCY OF SYNTHETIC SOMATOSTATIN IN OXIDIZED AND REDUCED FORM ON INHIBITION OF SECRETION OF GROWTH-HORMONE [J].

BRAZEAU, P ;

VALE, W ;

RIVIER, J ;

GUILLEMIN, R .

LIFE SCIENCES, 1974, 15 (02) :351-357

[5] ACYLATED DES-[ALA1-GLY2]-SOMATOSTATIN ANALOGS - PROLONGED INHIBITION OF GROWTH-HORMONE SECRETION [J].

BRAZEAU, P ;

VALE, W ;

RIVIER, J ;

GUILLEMIN, R .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1974, 60 (04) :1202-1207

[6] PRIMARY STRUCTURE OF SOMATOSTATIN - HYPOTHALAMIC PEPTIDE THAT INHIBITS SECRETION OF PITUITARY GROWTH-HORMONE [J].

BURGUS, R ;

LING, N ;

BUTCHER, M ;

GUILLEMI.R .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1973, 70 (03) :684-688

[7] EFFECTS OF SOMATOSTATIN ON PLASMA GLUCOSE AND GLUCAGON LEVELS IN HUMAN DIABETES-MELLITUS - PATHOPHYSIOLOGIC AND THERAPEUTIC IMPLICATIONS [J].

GERICH, JE ;

LORENZI, M ;

SCHNEIDER, V ;

KARAM, JH ;

RIVIER, J ;

GUILLEMIN, R ;

FORSHAM, PH .

NEW ENGLAND JOURNAL OF MEDICINE, 1974, 291 (11) :544-547

[8]

HALL R, 1973, LANCET, V2, P581

[9]

HOPE DB, 1962, J BIOL CHEM, V237, P1563

[10] COLOR TEST FOR DETECTION OF FREE TERMINAL AMINO GROUPS IN SOLID-PHASE SYNTHESIS OF PEPTIDES [J].

KAISER, E ;

COLESCOT.RL ;

BOSSINGE.CD ;

COOK, PI .

ANALYTICAL BIOCHEMISTRY, 1970, 34 (02) :595-&

← 1 2 3 →