MOLECULAR STUDIES ON TRYPANOTHIONE REDUCTASE, A TARGET FOR ANTIPARASITIC DRUGS

被引：47

作者：

WALSH, C

BRADLEY, M

NADEAU, K

机构：

[1] C. Walsh, M. Bradley and K. Nadeau are, the Department of Biological Chemistry and Molecualr Pharmacology, Boston

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1991年 / 16卷 / 08期

关键词：

D O I：

10.1016/0968-0004(91)90124-E

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Trypanosoma and Leishmania are parasitic protozoa that cause a variety of diseases, which include African sleeping sickness and oriental sore. Attempts to determine pharmaceutically exploitable differences between host and parasite biochemistry have identified the unique trypanothione pathway as a possible target. This pathway includes the enzyme trypanothione reductase, the parasite analogue of glutathione reductase.

引用

页码：305 / 309

页数：5

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