INDUCTION OF SOS GENES OF ESCHERICHIA-COLI BY CHROMIUM COMPOUNDS

被引：47

作者：

LLAGOSTERA, M ^{[1
]}

GARRIDO, S ^{[1
]}

GUERRERO, R ^{[1
]}

BARBE, J ^{[1
]}

机构：

[1] UNIV AUTONOMA BARCELONA, INST FUNDAMENTAL BIOL, Bellaterra, SPAIN

来源：

ENVIRONMENTAL MUTAGENESIS | 1986年 / 8卷 / 04期

关键词：

D O I：

10.1002/em.2860080408

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The induction of several SOS genes of Escherichia coli such as recA, umuC, and sfiA by hexavalent (K2CrO7, K2CrO4, and CrO3) and trivalent (CrCl3, Cr(NO3)3, and (CH3COO)3Cr) compounds of chromium was studied. Induction was measured as .beta.-galactosidase activity, using lacZ gene fusions under the control region of different SOS genes. The hexavalent chromium forms induced the genes responsible for massive synthetic or RecA protein, error-prone repair, and inhibition of cell division. On the other hand, the trivalent chromium compounds were unable to induce any of the SOS genes tested. Individual assay of hexavalent chromium compounds showed that K2Cr2O7 was a stronger inducing agent of those three SOS genes tested than K2CrO4, which, in turn, was stronger than CrO3. All this data led to the conclusion that hexavalent chromium compounds, but not trivalent, are proficient agents of induction of the SOS system and can produce indirect mutagenesis in Escherichia coli.

引用

页码：571 / 577

页数：7

共 24 条

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