THE ROLE OF G-PROTEINS VERSUS PROTEIN TYROSINE KINASES IN THE REGULATION OF LYMPHOCYTE-ACTIVATION

被引：53

作者：

HARNETT, M ^{[1
]}

RIGLEY, K ^{[1
]}

机构：

[1] CELLTECH LTD,CELLTECH RES,DEPT IMMUNOMODULAT,SLOUGH SL1 4EN,ENGLAND

来源：

IMMUNOLOGY TODAY | 1992年 / 13卷 / 12期

关键词：

D O I：

10.1016/0167-5699(92)90022-Y

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The relative roles of G-proteins and protein tyrosine kinases (PTKs) in the regulation of antigen receptor-mediated signalling in B and T cells is controversiaL As they, and the biochemical events they control, are potential targets for intervention in various immune dysfunctions, the resolution of the controversy is of great interest. Here, Margaret Harnett and Kevin Rigley provide a timely assessment of current understanding, and propose a model for the interaction of G-proteins and PTKs in antigen receptor-mediated signalling.

引用

页码：482 / 486

页数：5

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