A POPULATION-BASED TWIN STUDY OF ALCOHOLISM IN WOMEN

被引:342
作者
KENDLER, KS
HEATH, AC
NEALE, MC
KESSLER, RC
EAVES, LJ
机构
[1] WASHINGTON UNIV,SCH MED,DEPT PSYCHIAT,ST LOUIS,MO 63110
[2] UNIV MICHIGAN,INST SOCIAL RES,ANN ARBOR,MI 48109
[3] VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT HUMAN GENET,RICHMOND,VA 23298
来源
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION | 1992年 / 268卷 / 14期
关键词
D O I
10.1001/jama.268.14.1877
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective.-To clarify the role of genetic factors in the etiology of alcoholism in women. Design and Setting.-Personal structured psychiatric interviews conducted by researchers "blinded" to the status of the co-twin in an epidemiologic sample of 1030 female-female twin pairs of known zygosity from the population-based Virginia Twin Registry. Measures.-Three definitions of lifetime prevalence of alcoholism based on Diagnostic and Statistical Manual of Mental Disorders, Third Edition, Revised criteria: (1) alcoholism with tolerance or dependence; (2) alcoholism with or without tolerance-dependence; and (3) alcoholism with or without tolerance-dependence or problem drinking. Results.-Using narrow, intermediate, or broad definitions, the probandwise concordance for alcoholism was consistently higher in monozygotic than in dizygotic twin pairs. Multifactorial threshold models suggested that the heritability of liability to alcoholism in women is in the range of 50% to 60%. Conclusions.-The results support the hypothesis that genetic factors play a major role in the etiology of alcoholism in women. Women should be well represented in the efforts currently under way to elucidate the molecular basis of the genetic susceptibility to alcoholism.
引用
收藏
页码:1877 / 1882
页数:6
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